Preparation and adsorption performance research of large-volume hollow mesoporous polydopamine microcapsules
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esearch Letter
Preparation and adsorption performance research of large-volume hollow mesoporous polydopamine microcapsules Caihong Tao, Tiandi Chen, Hui Liu, and Sisi Su, School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P. R. China Address all correspondence to Caihong Tao at [email protected] (Received 28 November 2018; accepted 9 April 2019)
Abstract Hollow mesoporous polydopamine (HMPDA) microcapsules were prepared by a template method using silica nanoparticles as the templates. The template method was also used for the formation of mesoporous polydopamine (PDA), which is driven by π–π interactions of trimethylbenzene and PDA, in which the PDA wall with mesoporous structure can be obtained after template removal by extraction. Because of its surface mesoporous structure and large central cavity structure, HMPDA microcapsules have unique adsorption properties. Compared with other porous materials, PDA has better biosafety because dopamine itself is a bionic material. The above properties are of great significance for the application of HMPDA microcapsules in the field of biologic medicine, especially in drug carriers.
Introduction Mesoporous materials have attracted the attention of many researchers because of their many properties, including a high degree of pore order on the micrometer scale, narrow poresize distribution,[1] high surface area,[2] excellent thermal stability,[3] and hydrothermal stability.[4] Therefore, they have been applied in many fields, such as chemistry, optoelectronics, electromagnetism, materials science, and environmental science.[5–7] Mesoporous materials have also been used as nanocarriers in the biomedical field owing to their super-porous structure and adsorption properties.[8–10] It is of technical interest to produce a shell-like capsule in which release is controlled by permeation through the shell material, but the eventual collapse of the capsule makes it difficult to ensure the mechanical stability of the coating as a whole.[5] Environmentally friendly carbon and silica materials appear to be ideal mesoporous sources because of their low-cost and unique mechanical, thermal, and chemical properties.[11–13] For example, Valdés-Solís et al. fabricated hollow mesoporous carbon capsules in nanosized catalysts.[14] Adhikari et al. synthesized mesoporous silica and hollow mesoporous silica spheres applied for chemotherapeutic drug delivery.[1] However, the preparation process required calcination,[15] harsh conditions, and high energy consumption.[16] Chen et al. synthesized mesoporous polydopamine (MPDA) nanoparticles with the triblock copolymer pluronic F127 (EO106PO70EO106) and trimethylbenzene (TMB) as the organic templates.[17] Polydopamine (PDA) has better biologic safety and biodegradability than carbon and silica materials as dopamine itself is a biomimetic material. Furthermore, because the reactive groups include both amino
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and catechol groups of PDA, it can be used as an ideal secondary reaction platform, which is also ver
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