Preparation and Anti-microbial Performance of Ni 0.5 Zn 0.5 Fe 2 O 4 @Ag Nanocomposites
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Preparation and Anti‑microbial Performance of Ni0.5Zn0.5Fe2O4@Ag Nanocomposites Shuai Pan1 · Qingmei Yu1 · Lulu Yu1 · Yueyang Xu2 · Ruijiang Liu1 Received: 8 July 2020 / Accepted: 22 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Pathogens are harmful to humans and can lead to death in severe cases. Silver nanoparticles are considered to be the most effective antibacterial materials. Therefore, the magnetic NZFO@Ag-R nanocomposites were prepared by the reduction method with magnetic Ni0.5Zn0.5Fe2O4 nanoparticles, silver nitrate, and sodium citrate as raw materials. The antibacterial performances of the materials were evaluated by the growth curve, the inhibition zone test, the minimum inhibitory concentration (MIC) test, and the minimum bactericidal concentration (MBC) test with E. coli and S. aureus as the bacterial source. The XRD, SEM, and VSM characterization results showed that the magnetic NZFO@Ag-40% nanocomposites had a spherical morphology with an average size of 23 nm. The Ag loaded had a cubic crystal structure and evenly mixed with NZFO. The mass fraction of silver was 31.34%. The saturation magnetization decreased from 63.7 emu/g to 31.6 emu/g with the increase of Ag content. The antibacterial circle test and growth curve test explained that NZFO nanoparticles had almost no antibacterial properties. When the Ag content reached 40%, the radius of the antibacterial circle was the largest and the inhibition effect of the growth curve was the most obvious. When the content raised to 50%, the antibacterial activity was not significantly enhanced. The MIC and MBC of the magnetic NZFO@Ag-40% nanocomposites for E. coli were 5 µg/mL. The MIC and MBC for S. aureus were 5 µg/mL and 10 µg/mL, respectively. The possible mechanism was proposed for the improved antibacterial activity of NZFO@Ag-R nanocomposites. Keywords Ni0.5Zn0.5Fe2O4@Ag-R nanocomposites · Antibacterial activity · E. coli · S. aureus · Magnetic separation · Antibacterial mechanism
1 Introduction The high incidence of diseases and infectious diseases caused by pathogens has always caused great concern, which has a negative impact on regional and national economies and leads to serious deaths [1–3]. It is costly to solve these infectious diseases. Some of these infections have been wiped out, but a few of those were thought to have been back and resistant to modern medicine [4, 5]. The main cause of the resistance is the misuse and incomplete use of antibiotics, leading to the development of antibodies against specific antibiotics. Hence, pathogens still do great harm * Ruijiang Liu [email protected] 1
School of Pharmacy, Jiangsu University, Zhenjiang 212013, People’s Republic of China
Guo Dian Science and Technology Research Institute Co. Ltd, Nanjing 210031, People’s Republic of China
2
to humans [6–8]. Moreover, the spread of these diseases is very frequent, especially in the absence of appropriate antibiotics to deal with the problems [9, 10]. Antibiotics, chemical disinfectants
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