Preparation of cytocompatible luminescent and magnetic nanohybrids based on ZnO, Zn 0.95 Ni 0.05 O and core@shell ZnO@Fe
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RESEARCH PAPER
Preparation of cytocompatible luminescent and magnetic nanohybrids based on ZnO, Zn0.95Ni0.05O and core@shell ZnO@Fe2O3 polymer grafted nanoparticles for biomedical imaging I. Balti • A. Barre`re • V. Gueguen • L. Poussard G. Pavon-Djavid • A. Meddahi-Pelle´ • P. Rabu • L. S. Smiri • N. Jouini • F. Chaubet
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Received: 20 July 2012 / Accepted: 25 October 2012 / Published online: 13 November 2012 Ó Springer Science+Business Media Dordrecht 2012
Abstract ZnO, Zn0.95Ni0.05O and core@shell ZnO@ c-Fe2O3 nanoparticles (NPs) have been prepared by forced hydrolysis in polyol medium and then coated via the ‘‘grafting from’’ approach with poly(sodium-4styrenesulfonate) and poly(sodium-4-styrenesulfonate– co–sodium methacrylate) in the case of ZnO. The surface-initiated atom transfer radical polymerization
Electronic supplementary material The online version of this article (doi:10.1007/s11051-012-1266-x) contains supplementary material, which is available to authorized users. I. Balti L. S. Smiri De´partement de Chimie, Unite´ de recherche UR11ES30, Faculte´ des sciences de Bizerte, Universite´ de Carthage, 7021 Jarzouna, Tunisia e-mail: [email protected] L. S. Smiri e-mail: [email protected] I. Balti N. Jouini Laboratoire de Sciences des Proce´de´s et des Mate´riaux, LSPM, CNRS UPR 3407, Institut Galile´e, Universite´ Paris 13, 99 Avenue J.B. Cle´ment, 93430, Villetaneuse, France e-mail: [email protected] A. Barre`re V. Gueguen L. Poussard G. Pavon-Djavid A. Meddahi-Pelle´ F. Chaubet (&) Laboratoire de bio-inge´nierie des polyme`res cardiovasculaires, Inserm U698, Institut Galile´e, Universite´ Paris 13, 99 Avenue J.B. Cle´ment, 93430, Villetaneuse, France e-mail: [email protected]
occurred from the surface-functionalized NPs with abromoisobutyric acid as initiator. The polymer chains were grown from the surface to yield hybrid NPs with a 1–3-nm thick organic shell. FT-IR, TGA and electron microscopy evidenced the presence of a polymer layer on the surface of NPs. Magnetic and optical properties of bare and coated NPs have been measured. Eventually, the weak cytotoxicity of coated NPs on human endothelial cell allows considering their potentialities as new tools for nanomedicine and biomedical imaging.
A. Barre`re e-mail: [email protected] V. Gueguen e-mail: [email protected] L. Poussard e-mail: [email protected] G. Pavon-Djavid e-mail: [email protected] A. Meddahi-Pelle´ e-mail: [email protected] P. Rabu De´partement de Chimie des Mate´riaux Inorganiques, IPCMS UMR7504, CNRS-UDS, 23, rue du Loess BP43, Strasbourg cedex 2, France e-mail: [email protected]
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Keywords Nanoparticles Zinc oxide SI-ATRP Poly(sodium-4-styrenesulfonate) Poly(sodium-4-styrenesulfonate–co–sodium methacrylate) Cytotoxicity
Introduction Encapsulation of inorganic nanoparticles (NPs) inside a polymer shell is the most popular and interesting approach to synthesize hybrid nanocomposites for biomedical a
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