Preparation and Properties of Zn-Cu Alloy for Potential Stent Material
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JMEPEG https://doi.org/10.1007/s11665-020-05167-0
Preparation and Properties of Zn-Cu Alloy for Potential Stent Material Jiajun Huang, Yonglai Lai, Hualan Jin, Hongmin Guo, Fanrong Ai, Qi Xing, Xiangjie Yang, and David J. Ross (Submitted March 25, 2020; in revised form September 4, 2020) Among degradable metal cardiac stent materials, zinc has great biocompatibility and corrosion properties, which make it become the most potential stent material. However, the mechanical properties of zinc cannot meet the performance requirements of stent material which severely limit its application. In this paper, ZnxCu (x = 1, 2 and 3 wt.%) alloys were prepared, and their mechanical properties, corrosion properties and biocompatibility were studied. Tensile testing showed the tensile strength and hardness of Zn-xCu alloys both increased with the addition of copper, but the elongation decreased at first and then upturned. Since the formation of galvanic cell, the corrosion rates of Zn-xCu alloys increased. The main corrosion mechanism of Zn-xCu alloy was pitting corrosion, and the corrosion products mainly included ZnO and Zn(OH)2. The cytotoxicity evaluation showed that Cu2+ and Zn2+ would contribute to cell proliferation, while the concentrations of them reached a suitable range like the concentration of soaking solution of Zn3Cu alloy was 25%. However, it would inhibit proliferation, while the concentrations of Zn2+ and Cu2+ were too large. In general, Zn-3Cu alloy had the best comprehensive properties. Keywords
biocompatibility, corrosion rate, properties, stent, zinc-copper alloys
mechanical
1. Introduction Percutaneous coronary intervention as an effective way to cure cardiovascular diseases had received widespread attention. Coronary stent could be divided into permanent stent and degradable stent. According to different types of materials, it also could be divided into metal stent, inorganic nonmetal stent and polymer stent. At now, metal stent is the most commonly used. Permanent metal cardiac stent materials mainly use titanium and titanium alloys. As applied materials, it has been studied extensively. Eren Yılmaz et al. (Ref 1, 2) researched Ti-Nb alloys and Ti-Nb-xZr alloys. It was founded that the increment of the porosity lowered the corrosion resistance in Ti-Nb alloys and the addition of Zr decreased the grain size and stabilized the b phase in Ti-Nb-xZr alloys. However, due to its nondegradable characteristic, a second operation was required to remove the stent, causing secondary injury to the human body, which turned the focus of researchers to the degradable metal cardiac stent materials. Jiajun Huang and Yonglai Lai are common first author. Jiajun Huang, Fanrong Ai, and Xiangjie Yang, School of Materials Science and Engineering, Nanchang University, Nanchang 330031, PeopleÕs Republic of China; Yonglai Lai, Hualan Jin, and Hongmin Guo, School of Mechanical and Electrical Engineering, Nanchang University, Nanchang 330031, PeopleÕs Republic of China; Qi Xing, Department of Cardiovascular Diseases, Mayo Clinic, R
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