Prevalence and Effect of Intestinal Infections Detected by a PCR-Based Stool Test in Patients with Inflammatory Bowel Di
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ORIGINAL ARTICLE
Prevalence and Effect of Intestinal Infections Detected by a PCR‑Based Stool Test in Patients with Inflammatory Bowel Disease Julajak Limsrivilai1,2 · Zachary M. Saleh1 · Laura A. Johnson1 · Ryan W. Stidham1 · Akbar K. Waljee1,3,4 · Shail M. Govani5 · Brian Gutermuth1 · Alexandra M. Brown1 · Emily Briggs1 · Krishna Rao6 · Peter D. R. Higgins1 Received: 9 October 2019 / Accepted: 12 January 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background The advent of PCR-based stool testing has identified a greatly increased number of infectious agents in IBD, but their clinical significance is unknown. Aims To determine the infectious agent prevalence and the clinical significance of these infectious agents in IBD patients. Methods This cross-sectional study compared the prevalence of GI infections among IBD patients with active and quiescent disease versus healthy controls. Among actively inflamed patients, we compared clinical characteristics, medication use, and disease course between those with positive and negative tests. Results Three hundred and thirty-three IBD patients and 52 healthy volunteers were included. The IBD group was divided into active Crohn’s disease (CD, n = 113), inactive CD (n = 53), active ulcerative colitis (UC, n = 128), and inactive UC (n = 39). A significantly higher percentage of actively inflamed patients had positive stool tests (31.1%) compared to those with quiescent disease (7.6%, P = 1.0 mg/dL, (2) active ulcerative colitis (UC) defined by a of Mayo score ≥ 3 with endoscopic subscore > 1, FCP > 200 µg/g of feces, or CRP level > 1.0 mg/dL, (3) quiescent CD defined by absence of documented ulceration on endoscopy, or CRP
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