Prevalence and variables associated with fatigue in psoriatic arthritis: a cross-sectional study
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Rheumatology International https://doi.org/10.1007/s00296-020-04678-2
INTERNATIONAL
OBSERVATIONAL RESEARCH
Prevalence and variables associated with fatigue in psoriatic arthritis: a cross‑sectional study Joel Shi Quan Tan1,2 · Warren Fong1,2,3 · Yu Heng Kwan3 · Ying Ying Leung1,2,3 Received: 2 May 2020 / Accepted: 3 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objective To describe the prevalence of and evaluate the factors associated with fatigue patients with psoriatic arthritis (PsA) in an Asian population. Methods We used baseline data from a registry of patients with PsA attending an outpatient clinic of a tertiary hospital in Singapore. Demographic data and disease characteristics were evaluated. Fatigue was assessed by question one of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI-F) and the vitality domain of the Medical Outcome Survey, ShortForm 36 (SF-36 VT). We evaluated clusters of variables, and individual variables in association with fatigue. Results We included 131 patients (50.4% men, 63.4% Chinese, median PsA duration 21.0 months) with completed data for fatigue. Forty-five patients (34%) experienced severe fatigue (defined by BASDAI-F > 5/10). We used principal component analysis and identified five clusters of variables that explained 62.9% of the variance of all factors. Of these, disease activity and impact, and disease chronicity were significantly associated with BASDAI-F and SF-36 VT. In multivariable analyses, back pain, peripheral joint pain and patient global assessment were associated with BASDAI-F, whereas peripheral joint pain and mental health were associated with SF-36 VT. Conclusion PsA-associated fatigue is prevalent in this Asian PsA cohort and is associated with disease activity, impact and chronicity. Keywords Arthritis · Psoriatic · Fatigue · Rheumatic diseases
Introduction Psoriatic arthritis (PsA) is a chronic autoimmune disease with musculoskeletal manifestations of arthritis, dactylitis, enthesitis and spondylitis associated with skin psoriasis. Fatigue is ranked among the three most important domains according to patients with PsA [1, 2]. Its significance is This work has previously been submitted for the eular congress 2020 with the following abstract publication (doi: 10.1136/ annrheumdis-2020-eular.2068): Tan Jsq, Fong W, Kwan Yh, Leung Yy (2020) ab0836 prevalence and determinants of fatigue in psoriatic arthritis in an asian population. Annals of the Rheumatic Diseases 79 (suppl 1):1723 Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00296-020-04678-2) contains supplementary material, which is available to authorized users. * Ying Ying Leung [email protected] Extended author information available on the last page of the article
formally recognised in the inner core of the OMERACT core set of domains and it is required to be reported in all clinical trials and longitudinal observational studies [3]. Fatigue has a detrimental impact on quality of l
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