Effectiveness of ustekinumab in patients with psoriatic arthritis in a real-world, multicenter study
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ORIGINAL ARTICLE
Effectiveness of ustekinumab in patients with psoriatic arthritis in a real-world, multicenter study A. B. Azuaga 1 & B. Frade-Sosa 1 & A. Laiz 2 & P. Estrada 3 & A. Prior-Español 4 & L. Horcada 5 & L. Polino 6 & M. Moreno 7 & C. Moragues 8 & A. Urruticoechea-Arana 9 & A. Sellas 10 & J. L. Tandaipan 11 & V. Torrente-Segarra 12 & J. Garcia-Miguel 13 & I. Ros 14 & S. Ordoñez 15 & P. Moya 2 & D. Reina 3 & L. Mateo-Soria 4 & C. Fito 5 & E. Beltrán 6 & M. Pujol 11 & A. M. Cuervo 1 & J. D. Cañete 1 & Julio Ramírez 1 & on behalf of ESPOCAT group Received: 27 January 2020 / Revised: 15 March 2020 / Accepted: 20 March 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Objective To assess the effectiveness and survival of ustekinumab (UST) among patients with psoriatic arthritis (PsA) treated under routine clinical care. Methods Multicenter study. Epidemiological and clinical data was collected through electronic medical records of all patients with PsA who started UST in 15 hospitals of Spain. Results Two hundred and one patients were included, 130 (64.7%) with 45 mg and 71 (35.3%) with 90 mg. One hundred and thirty one patients (65.2%) had previously received another biological therapy. The median baseline DAS 28 ESR was 3.99, and Psoriasis Area and Severity Index (PASI) was 3. Overall, there was a significant decrease in DAS66/68 CRP, swollen joint count (SJC), tender joint count (TJC), and PASI in the first month of treatment, with earlier improvement in skin (PASI) than joints outcomes. Survival was numerically lower in patients with UST 45 mg (58.1%) than 90 mg (76.1%), although significant differences were not found (p = 0.147). When comparing naïve and < 1 TNF blocker versus > 2 TNF blocker-experienced patients, a significantly earlier response was seen in the former group regarding SJC (p = 0.029) at 1 month. Fifty-one patients (25.3%) stopped UST due to joint inefficacy and 4 patients due to adverse events (1.9%). Drug survival was significantly better in patients with fewer lines of previous biological agents (p = 0.003 for < 1 TNF blocker versus > 2 TNF blocker users). Conclusions UST was effective in PsA patients in a routine clinical care setting. Patients with UST 90 mg and fewer lines of previous biologics achieved better and faster responses. Key Points • Largest cohort of patients with PsA in treatment with UST with specific rheumatological indication. • First cohort of patients with PsA comparing effectiveness of UST according to 45/90 mg dose.
Keywords Psoriatic arthritis . Tumor necrosis factor . Ustekinumab * Julio Ramírez [email protected]
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Rheumatology Department, Hospital Platò, Barcelona, Spain
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Rheumatology Department, Hospital Can Misses, Ibiza, Spain
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Arthritis Unit, Rheumatology Department, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain
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Rheumatology Department, Hospital Universitari Arnau de Vilanova, Lleida, Spain
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Rheumatology Department, Hospital Santa Creu i Sant Pau, Barcelona, Spain
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Rheumatology Department,
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