Primary Malignant Melanoma of the Lung: A Case Report
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Case report
Primary Malignant Melanoma of the Lung: A Case Report Apostolos Dountsis1, Charalambos Zisis*1, Evangelia Karagianni2 and Jubrail Dahabreh1 Address: 1Department of Thoracic Surgery, Athens Medical Center, Athens, Greece and 2Department of Pathology, Athens Medical Center, Athens, Greece Email: Apostolos Dountsis - [email protected]; Charalambos Zisis* - [email protected]; Evangelia Karagianni - [email protected]; Jubrail Dahabreh - [email protected] * Corresponding author
Published: 30 November 2003 World Journal of Surgical Oncology 2003, 1:26
Received: 05 August 2003 Accepted: 30 November 2003
This article is available from: http://www.wjso.com/content/1/1/26 © 2003 Dountsis et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
MalignantmelanomapulmonaryimmunohistochemistrypneumonectomyinterferonHMB-45S-100
Abstract Background: Primary melanoma of the lung is an extremely rare pathological entity and sparsely reported in the literature. Case presentation: A case of primary malignant melanoma of the lung in a 41-year-old female is reported. The clinical, radiological and histopathological features are discussed. The initial symptom was cough, whereas the chest radiography showed a round opacity of the right lung. The computed tomography of the chest revealed a well-demarcated mass lesion in the right upper lobe. Endobronchial mass causing obstruction of the upper lobar bronchus was the bronchoscopic finding. Patient underwent pneumonectomy. A diagnosis of melanoma was confirmed postoperatively after the immunohistochemistry. Primary nature of the tumour in the lung results from the demonstration of characteristic junctional pattern of melanoma cells beneath the bronchial epithelium on histopathology, and from exclusion of other potential primary sites in the clinical, paraclinical and laboratory examination. Conclusions: Primary melanoma of the lung represents a rare pathological entity. Careful interpretation of histopathological information in correlation with all other findings from clinical and paraclinical studies can establish a diagnosis. Follow-up is necessary in order to diagnose potential dissemination or secondary sites of the disease. Due to the small number of cases reported in the literature, there is no experience on the management and the prognosis of the disease, but surgical resection remains the cornerstone of the treatment.
Introduction Malignant melanoma (MM) is a malignant tumour, arising from the pigment producing cells (melanosomes) of the deeper layers of the skin (or the eye) and is the leading cause of death attributable to skin lesions. It is usually described as an irregular dark skin lesion that may have
areas of varying colour. The mucosal localizations, such as in the oral cavity, oesophagus, larynx, the ano-genital mucosa, and in ovarian cystic teratoma have bee
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