Primary Merkel Cell Carcinoma: A Retrospective Analysis of 31 Cases in Poland
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ORIGINAL RESEARCH
Primary Merkel Cell Carcinoma: A Retrospective Analysis of 31 Cases in Poland _ ´ ska Magdalena Cia˛zyn
. Katarzyna Szczepaniak . Marta Pabianek .
´ ska . Witold Owczarek . Dariusz Nejc . Adam Reich . Małgorzata Ułan Małgorzata Skibin´ska . Joanna Narbutt . Aleksandra Lesiak
Received: June 7, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine cancer that typically arises in sun-exposed areas of Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12594308. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13555020-00424-5) contains supplementary material, which is available to authorized users. _ ´ ska (&) K. Szczepaniak M. Pabianek M. Cia˛zyn M. Ułan´ska Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, Ło´dz´, Poland e-mail: [email protected] D. Nejc Department of Surgical Oncology Chair of Oncology, Medical University in Ło´dz´, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, Ło´dz´, Poland A. Reich Department of Dermatology, University of Rzeszow, Rzeszo´w, Poland W. Owczarek Dermatology Clinic, Military Institute of Medicine in Warsaw, Warsaw, Poland M. Skibin´ska J. Narbutt A. Lesiak Department of Dermatology, Paediatric Dermatology and Oncology Clinic, Medical University of Ło´dz´, Ło´dz´, Poland
the skin, especially in the elderly. Significant advances have recently been made regarding skin cancers, but data on cases of MCC are rather limited as these patients are frequently grouped together with other non-melanoma skin cancers (NMSC). Here, we performed an analysis of the clinical profile of patients with MCC in Poland to identify major factors influencing the prognosis. Methods: Approximately 13,000 pathology and medical records were examined to identify patients with MCC diagnosed between 2010 and 2019. The management and outcomes of patients with histologically confirmed MCC were retrospectively evaluated. Results: Thirty-one patients diagnosed with MCC were identified. The tumor occurred predominantly in women (61.3%) and in the elderly (mean 75.6 years). Twenty-nine patients had locoregional MCC and two had metastatic MCC at the time of diagnosis. Patients in stage I disease had excellent prognosis. In stages II and III, respectively 22.2% and 50.0% of patients developed metastases. Among patients who received chemotherapy with cisplatin and etoposide, 17% achieved partial remission with progression-free survival (PFS) of 8.0 months, and a further 50% achieved stable disease with PFS of 4.0, 4.5, and 4.5 months respectively. In 6 (19.4%) patients MCC coexisted with chronic lymphocytic leukemia (CLL). In all six cases CLL preceded MCC development.
Dermatol Ther (Heidelb)
Conclusions: Female gender, tumor-free resection margins, and local disease were found to be independent prognostic factors in MCC p
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