Primary multifocal osseous Hodgkin's lymphoma
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Primary multifocal osseous Hodgkin's lymphoma Clare R Langley*1, Simon JW Garrett2, Jill Urand3, Janice Kohler3 and Nick MP Clarke3 Address: 1Orthopaedic Department, Basingstoke and North Hampshire Foundation Trust, Aldermaston Road, Basingstoke, Hampshire, RG24 9NA, UK, 2Royal Bournemouth Hospital, Castle Lane East, Bournemouth, Dorset, BH7 7DW, UK and 3Southampton University Hospitals NHS Trust, Tremona Road, Southampton, SO16 6YD, UK Email: Clare R Langley* - [email protected]; Simon JW Garrett - [email protected]; Jill Urand - [email protected]; Janice Kohler - [email protected]; Nick MP Clarke - [email protected] * Corresponding author
Published: 17 March 2008 World Journal of Surgical Oncology 2008, 6:34
doi:10.1186/1477-7819-6-34
Received: 17 July 2007 Accepted: 17 March 2008
This article is available from: http://www.wjso.com/content/6/1/34 © 2008 Langley et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Hodgkin's disease (HD) most commonly presents with progressive painless enlargement of peripheral lymph nodes, especially around the cervical region. A few children have systemic symptoms and weight loss. At the time of diagnosis, osseous involvement is uncommon Case presentation: A case is described of Primary Multifocal Osseous Hodgkin's Lymphoma in a seven-year-old boy. He presented with a painful swelling in the sternum, and further investigations revealed deposits in his L1 vertebra, the left sacro-iliac joint and the right acetabulum. Conclusion: The clinical, radiological and histological features of this disease can mimic other medical conditions, including Tuberculosis, making the diagnosis difficult and often leading to delays in treatment. This is a very rare condition and we believe this to be the youngest reported case in the literature.
Background Hodgkin's disease (HD) most commonly presents with progressive painless enlargement of peripheral lymph nodes, especially around the cervical region. A few children have systemic symptoms and weight loss. At the time of diagnosis, osseous involvement is uncommon and even in the late stages only 9–35% of cases have any bony involvement [1]. It is therefore extremely rare for patients to present with primary Hodgkin's disease of the bone. If there is no associated extra-osseous involvement, the condition is referred to as primary osseous Hodgkin's lymphoma (POHL). It is termed primary multifocal osseous Hodgkin's lymphoma, if more than one osseous site is involved. The clinical, radiological and histological features of POHL can mimic other medical conditions,
thereby making the diagnosis difficult, often leading to delays in treatment We present a case of a seven-year-old boy diagnosed with primary multifocal osse
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