Primary Non-Hodgkin Lymphoma of Prostate: a Case Report
- PDF / 2,591,496 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 34 Downloads / 231 Views
CASE REPORT
Primary Non-Hodgkin Lymphoma of Prostate: a Case Report R. B. Nerli 1 & Adarsh Sanikop 2 & Manas Sharma 1 & Priyeshkumar Patel 1 & Ranjit Kangale 2 & Shashank Patil 1 & Shridhar C. Ghagane 3 & Murigendra B. Hiremath 4 & Neeraj S. Dixit 3 Received: 2 April 2020 / Accepted: 19 August 2020 # Indian Association of Surgical Oncology 2020
Introduction
Case Report
Primary malignant non-Hodgkin lymphoma (NHL) of the prostate, presenting as primary extranodal lymphoma, is very rare and so is the secondary spread of lymphoma to the prostate from other sites. The diagnosis of NHL in extranodal locations such as the prostate is challenging as carcinoma is known to mimic lymphoma on histologic examination [1, 2]. Several experts had challenged the existence of primary extranodal prostatic NHL due to the paucity of lymphoid tissue in the prostate [1, 3]. However, rudimentary lymphoid nodules [4] and extra medullary hematopoiesis [5] have been recognized in the prostate. Moreover, histologic documentation of cases with involvement limited to the prostate without retroperitoneal lymph node involvement has confirmed the existence of NHL primary to the prostate. To label any lesion as a primary prostatic lymphoma, Bostwick et al. [1] suggested three criteria that include (1) symptoms attributable to prostatic enlargement and tumor limited to the prostate and adjacent soft tissues; (2) involvement of the prostate predominantly, with or without involvement of adjacent tissue [6]; and (3) absence of involvement of the liver, spleen, or lymph nodes within 1 month of diagnosis of the prostatic involvement [7]. We report a case of primary non-Hodgkin lymphoma of the prostate in a 73-year-old male.
A 73-year-old male was admitted to the urological services of the hospital, with acute retention of urine. He was catheterized and referred to our hospital. He was known to be having lower urinary tract symptoms for over past 3 years. There was no history of any systemic symptoms like fever, weight loss, or night sweats. Clinical examination was unremarkable. Routine hematological and biochemical investigations were within normal limits except elevated serum PSA levels (46.83 ng/ml). A transabdominal sonography revealed an enlarged prostate of 147 cc. There was a well-defined echogenic area in the region of left lateral lobe measuring 3.5 × 3.1 cms (Fig. 1). Multiparametric magnetic resonance imaging (MRI) revealed a grossly enlarged prostate measuring 7.0 × 6.1 × 6.5 cms (Fig. 1b, c, d). The intravesical portion measured 1.4 cms. Transition zone showed multiple well-defined T2 intense, heterogeneously enhancing nodules, with no areas of diffusion restriction on DW1 sequence. There was a large nodule measuring 3.3 × 3.4 × 3.6 cms on the left side causing mass effect on posterior wall of the urinary bladder. Computed tomography of the abdomen and pelvis showed no evidence of hepatosplenomegaly or lymph node enlargement (Figs 2 and 3). A TRUS (transrectal ultrasonography) guided 12 core biopsy was done, and the histopathological r
Data Loading...
