Principles of Cancer Biotherapy
At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncol
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Principles of Cancer Biotherapy 5th Edition
Edited by Robert K. Oldham Hematology-Oncology Associates of Southeast Missouri Hospital Southeast Medical Plaza Cape Girardeau, MO USA
Robert O. Dillman Hoag Cancer Center Newport Beach, CA USA University of California Irvine, CA USA
Robert K. Oldham Hematology-Oncology Associates of Southeast Missouri Hospital Southeast Medical Plaza Cape Girardeau, MO USA
Robert O. Dillman Hoag Cancer Center Newport Beach, CA USA University of California Irvine, CA USA
e-ISBN 978-90-481-2289-9 ISBN 978-90-481-2277-6 DOI 10.1007/978-90-481-229-9 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009929387 First edition published 1987 by Raven Press Second edition published 1993 by Williams & Wilkins Third and Fourth edition published 1998 Kluwer Academic Publishers © Springer Science+Business Media B.V. 2009 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The idea for the first edition of Principles of Cancer Biotherapy was formulated in the early 1980s. As the founding director of the Biological Response Modifiers Program for the National Cancer Institute from 19801984, one of us (rko) envisioned a textbook that would embody the principles of the then fledgling fourth modality of cancer treatment - biotherapy. Contributing authors were solicited in 1985, and the first edition came off the presses in 1987. Principles represented the first comprehensive textbook on the use of cancer biotherapy and summarized the work done in this field through 1986. The second edition of Principles was published in 1991 about the time biotherapy was more broadly recognized as the fourth major cancer treatment modality. Subsequent textbooks by DeVita, Hellman and Rosenberg [1] in 1991, Mitchell [2] in 1993 and Rosenberg [3] in 2000 validated the importance of this modality in cancer care. This third edition was published in 1998 and confirmed the tremendous progress that had been made in the previous five years using biologicals in cancer treatment. It was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy was emerging as a more specific and targeted form of systemic cancer treatment. Cancer growth control was also becoming an effective method of treatment complementing cancer destruction as mechanisms of cancer treatment and “cure”. The fourth edition of Principles was published in 2003. It was apparent that biotherapy and the use of biopharmaceuticals had not only become recognized as the fourth modality of cancer treatment, it was cle
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