Printing composite nanofilaments for use in a simple and low-cost 3D pen
- PDF / 717,694 Bytes
- 9 Pages / 584.957 x 782.986 pts Page_size
- 58 Downloads / 201 Views
Printing composite nanofilaments for use in a simple and low-cost 3D pen Francisca Pereira de Araujo1,c), Igor Tadeu Silva Batista2,c), Francílio Carvalho de Oliveira3,c), Layane Rodrigues de Almeida1,c), Guilherme de Castro Brito3,c), Hernane da Silva Barud2,c), Dalton Dittz4,c), Edson Cavalcanti Silva-Filho1,c), Josy Anteveli Osajima1,a), Anderson Oliveira Lobo1,b) 1
LIMAV—Interdisciplinary Laboratory for Advanced Materials, UFPI—Federal University of Piaui, Teresina, Piauí 64049-550, Brazil Research Center on Biotechnology—Uniara, Araraquara, São Paulo 14801-340, Brazil 3 Universidade Estácio, Teresina, Piauí 64 046-700, Brazil 4 Biochemistry and Pharmacology Department, Federal University of Piauí, Teresina, Piauí 64049-550, Brazil a) Address all correspondence to these authors. e-mail: [email protected] b) e-mail: [email protected] c) These authors contributed equally to this work. 2
Received: 26 November 2019; accepted: 17 March 2020
In this work, filament based on e-polycaprolactone (PCL) and containing the bioactive ceramics nanohydroxyapatite (nHap) and Laponite (Lap) was prepared by the extrusion process. To obtain the material, a mass ratio of 89:10:1 (PCL:nHap:Lap) was used, and structural and morphological characterization was realized. In addition, cytotoxicity (using Allium cepa bulbs) and viability tests on L929 cells also were performed. The results showed that filament (diameter of 1.79 ± 0.17 mm) presented a good dispersion of nHap and Lap into polymeric matrices. Fourier transform infrared spectroscopy identified typical bands at 1720, 1091, and 1045 cm−1 addressed to PCL and nHAp, In addition, Lap was identified through dispersive energy system and Xray diffraction analyses. All filaments did not exhibit cytotoxic effects.
Introduction Additive manufacturing (AM) has promoted the development of structures for biomedical applications, especially for bone applications. Although it is considered a recent model of prototyping, this technology is used by researchers mainly because it produces materials with regenerative tissue capacity [1, 2]. Thus, many studies have reported on the fabrication of 3D scaffolds to induce bone formation because the process of cell proliferation and differentiation are directly related to the topography of the material [3, 4, 5]. Several different procedures are used to obtain threedimensional materials using AM, such as selective laser sintering [6], fused deposition modeling [7], and others [8]. Compared with the other techniques for obtaining biomaterials, which include electrospinning, solvent casting, and others, the use of 3D printing does not prejudice the biocompatibility of the biomaterial because toxic solvents are not used [7]. Although AM is an innovative and effective technique to produce materials that are perfectly suited to human anatomy
ª Materials Research Society 2020
[9, 10, 11], 3D printers are generally expensive and cannot be easily purchased. A commercial accessory that is based on the principle of extruding and molding parts for handling
Data Loading...
