Proceedings of the Seventeenth International Society of Sports Nutrition (ISSN) Conference and Expo
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Proceedings of the Seventeenth International Society of Sports Nutrition (ISSN) Conference and Expo Daytona Beach, FL, USA. 11-12 September 2020 Published: 30 November 2020
A1. Methylliberine (Dynamine™) and theacrine (TeaCrine®) magnify indices of cognitive affect when combined with coffee B. Raub1, K. Cesareo1, M. Carney1, C. Kerksick2, J. Sandrock1 1 The Center for Applied Health Sciences, Canfield, OH, 44406, USA; 2 School of Health Sciences, Lindenwood University, MO, 63301, USA Correspondence: B. Raub ([email protected]) Journal of the International Society of Sports Nutrition 2020, 17(Suppl 2):A1. Background Methylliberine (Dynamine™) and theacrine (TeaCrine®) are purine alkaloids with pronounced neuro-energetic effects. Based on their pharmacokinetic and pharmacodynamic interaction with caffeine (i.e. threefold increase in AUC vs. caffeine alone [https://pubmed.ncbi.nlm.nih.gov/32829142]), we theorized that combining these compounds with coffee (Coffea arabica) would magnify the beneficial effects of coffee on cognitive affect. Methods This randomized, double-blind, within-subject crossover trial of 15 male (N=7) and female (N=8) subjects (mean ± age, height, weight: 32.1 ± 9.6 y, 172.9 ± 9.5 cm, 77.5 ± 19.5 kg) assessed perceived changes in eight indices of cognitive affect after the ingestion of coffee plus several combinations of Dynamine™ and TeaCrine®. Using a Latin Square approach to minimize potential order effects, subjects ingested five different combinations of coffee: 1) 8 oz decaffeinated coffee (DECAF), 2) 8 oz regular coffee (COF), 3) 8 oz regular coffee + 50 mg Dynamine™ (COF-D50), 4) 8 oz regular coffee + 50 mg Dynamine™ and 25 mg TeaCrine® (COF-DT), and 5) 8 oz regular coffee + 100 mg Dynamine (COFD100) and filled out anchored visual analogue scales (VAS) that assessed perceived changes in mood, energy, fatigue, alertness, focus, creativity, concentration, and motivation at 0, 60, 120, and 180 min post-ingestion. Systemic hemodynamics (heart rate, blood pressure, rate pressure product, pulse pressure) were also assessed hourly during each trial. Statistical analyses (mixed factorial ANOVA and paired t-tests) were completed by an independent statistician who was blinded to treatments. Results As anticipated, DECAF only improved one VAS (focus, +9.6%, p=0.04) whereas all other treatments improved all eight VAS indices. Mixed factorial ANOVAs revealed positive changes from baseline for COF-DT in mood (+39.4%, p=0.02), energy (+70.8%, p=0.01), and motivation
(+49.3%, p=0.03) and trends for improvements in fatigue (-50.4%, p= 0.09), alertness (+48.5%, p=0.08), and focus (+60%, p=0.08). Compared to COF, COF-DT tended to reduce fatigue at 180 min (-32%, p=0.09). Aside from a small increase in diastolic blood pressure at 180 min (+4.3 ± 5.1 mm Hg, p=0.04) in COF-D50, no other changes in systemic hemodynamics were noted between treatments. Conclusions These findings confirm that combining Dynamine™ and TeaCrine® with caffeinated coffee significantly magni
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