Prognostic significance of vasohibin-1 and vasohibin-2 immunohistochemical expression in gastric cancer
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ORIGINAL ARTICLE
Prognostic significance of vasohibin‑1 and vasohibin‑2 immunohistochemical expression in gastric cancer Hitoshi Hara1 · Soji Ozawa1 · Yamato Ninomiya1 · Miho Yamamoto1 · Mika Ogimi1 · Kazuhito Nabeshima1 · Kenji Nakamura1 · Hiroshi Kajiwara2 · Naoya Nakamura2 · Yasufumi Sato3 Received: 29 February 2020 / Accepted: 27 April 2020 © Springer Nature Singapore Pte Ltd. 2020
Abstract Purpose It was recently identified that the vasohibin family may regulate angiogenesis through suppression by the vasohibin-1 gene and promotion by the vasohibin-2 gene. We assessed vasohibin expression in gastric cancer patients and its effect on their prognosis. Methods We evaluated vasohibin immunohistochemical expression in 210 patients with gastric cancer, who underwent radical surgery. The patients were divided first into a vasohibin-1-positive group and a vasohibin-1-negative group, and then into groups with high or low vasohibin-2 expression, to allow us to investigate the clinicopathological factors of prognosis retrospectively. Results There were 139 patients in the vasohibin-1-positive group and 71 patients in the vasohibin-1-negative group, among which there were and 108 with high vasohibin-2 expression and 102 with low vasohibin-2 expression. Vasohibin-1 was associated with Ly (P = 0.003) and pT (P = 0.037), whereas vasohibin-2 was associated with Ly (P
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