Prognostic value of myocardial perfusion imaging with D-SPECT camera in patients with ischemia and no obstructive corona
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Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China Department of Cardiology, Clinical Medical College of Shanghai Tenth People’s Hospital, Nanjing Medical University, Shanghai, China Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Received Dec 21, 2019; accepted Jun 1, 2020 doi:10.1007/s12350-020-02252-8
Background. Myocardial perfusion imaging (MPI) with a novel D-SPECT camera maintains excellent prognostic value compared to conventional SPECT. However, information about the relationship between D-SPECT MPI and the prognosis in patients with ischemia and no obstructive coronary artery disease (INOCA) is limited. The objective of this study was to evaluate the prognostic value of MPI with D-SPECT in INOCA and obstructive coronary artery disease (CAD) patients. Methods. All consecutive patients with suspected CAD and without prior CAD who underwent D-SPECT MPI and invasive coronary angiography within 3 months were considered. INOCA and obstructive CAD were defined as < 50% and ‡ 50% coronary stenosis, respectively. Patients were followed-up for the occurrence of major adverse cardiac events (MACE: cardiovascular death, nonfatal myocardial infarction, revascularization, stroke, heart failure and angina-related rehospitalization). Results. Among 506 patients, 232 (45.8%) were INOCA patients. A total of 33.2% of the INOCA patients had abnormal D-SPECT MPI, whereas 77.7% of the obstructive CAD patients had abnormal D-SPECT MPI. In both groups, patients with abnormal D-SPECT MPI demonstrated higher MACE rates and lower survival free of MACE. In addition, patients with INOCA and abnormal D-SPECT MPI had a poor prognosis similar to that of the obstructive Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12350-020-02252-8) contains supplementary material, which is available to authorized users. The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarizes the contents of the paper and is free for re-use at meetings and presentations. Search for the article DOI on SpringerLink.com. All editorial decisions for this article, including selection of reviewers and the final decision, were made by guest editor Daniel S. Berman, MD. Funding This work was supported by the National Natural Science Foundation of China (81570436), Foundation of Shanghai
Municipal Commission of Health and Family Planning (201640053), Shanghai Medical Guiding Project (124119a6900), and Foundation of Chongming (CKY2017-16, CKY2018-18). Reprint requests: Zhongwei Lv, MD, PhD, Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai200072, China; [email protected] 1071-3581/$34.00 Copyright Ó 2020 American Society of Nuclear Cardiology.
L. Liu et al. Prognostic value of D-SPECT MPI in INOCA
Journal of Nuclear CardiologyÒ
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