Prognostic value of SPECT myocardial perfusion entropy in high-risk type 2 diabetic patients
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ORIGINAL ARTICLE
Prognostic value of SPECT myocardial perfusion entropy in high-risk type 2 diabetic patients Loïc Djaileb 1,2 & Alexandre Seiller 2 & Marjorie Canu 2,3 & Nicolas De Leiris 1,2 & Alix Martin 4 & Julie Poujol 2 & Alicia Fraguas-Rubio 2 & Julien Leenhardt 1,2 & Adrien Carabelli 2,3 & Alex Calizzano 1,2 & Marie De Fondaumière 2 & Alexis Broisat 2 & Michel Desvignes 5 & Gérald Vanzetto 2,3 & Catherine Ghezzi 2 & Daniel Fagret 1,2 & Laurent M. Riou 2 & Gilles Barone-Rochette 2,3 Received: 30 June 2020 / Accepted: 8 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Risk stratification of patients with type 2 diabetes mellitus (T2D) remains suboptimal. We hypothesized that myocardial perfusion entropy (MPE) quantified from SPECT myocardial perfusion images may provide incremental prognostic value in T2D patients independently from myocardial ischemia. Methods T2D patients with very high and high cardiovascular risk were prospectively included (n = 166, 65 ± 12 years). Stress perfusion defect was quantified by visual evaluation of SPECT MPI. SPECT MPI was also used for the quantification of rest and stress MPE. The primary end point was major adverse cardiac events (MACEs) defined as cardiac death, myocardial infarction (MI), and myocardial revascularization > 3 months after SPECT. Results Forty-four MACEs were observed during a 4.6-year median follow-up. Significant differences in stress MPE were observed between patients with and without MACEs (4.19 ± 0.46 vs. 3.93 ± 0.40; P ≤ .01). By Kaplan-Meier analysis, the risk of MACEs was significantly higher in patients with higher stress MPE (log-rank P ≤ 01). Stress MPE and stress perfusion defect (SSS ≥ 4) were significantly associated with the risk of MACEs (hazard ratio 2.77 and 2.06, respectively, P < .05 for both) after adjustment for clinical and imaging risk predictors as identified from preliminary univariate analysis. MPE demonstrated incremental prognostic value over clinical risk factors, stress test EKG and SSS as evidenced by nested models showing improved Akaike information criterion (AIC), reclassification (global continuous net reclassification improvement [NRI]: 63), global integrated discrimination improvement (IDI: 6%), and discrimination (change in c-statistic: 0.66 vs 0.74). Conclusions Stress MPE provided independent and incremental prognostic information for the prediction of MACEs in diabetic patients. Trial registration number NCT02316054 (12/12/2014). Keywords SPECT . Myocardial perfusion . Perfusion entropy . Prognosis . Diabetes
Laurent M. Riou and Gilles Barone-Rochette contributed equally to this work. This article is part of the Topical Collection on Cardiology * Loïc Djaileb [email protected] 1
Nuclear Medicine Department, Grenoble-Alpes University Hospital, Grenoble, France
2
Radiopharmaceutiques Biocliniques, UMR UGA-INSERM U1039, Grenoble, France
3
Cardiology Department, Grenoble-Alpes University Hospital, Grenoble, France
4
Cardiology Department, Clinique Mutualiste,
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