Prospective evaluation of 68 Ga-PSMA-11 PET/CT in Chinese men with biochemical recurrence after radical prostatectomy fo
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ORIGINAL PAPER
Prospective evaluation of 68Ga‑PSMA‑11 PET/CT in Chinese men with biochemical recurrence after radical prostatectomy for prostate cancer: relationships between location of recurrence, time after prostatectomy, and serum PSA level Liang Dong1,2 · Yinjie Zhu1 · Mei Xin3 · Baijun Dong1 · Jiahua Pan1 · Jianjun Liu3 · Sarah R. Amend2 · Wei Xue1 · Kenneth J. Pienta2 · Steven P. Rowe2,4 Received: 19 May 2020 / Accepted: 22 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The purpose of this study was to prospectively evaluate the distribution of PSMA-targeted, PET-avid lesions in prostate cancer (PCa) patients with biochemical recurrence in a Chinese cohort. The relationships between PSA levels, disease-free time after prostatectomy, and 68Ga-PSMA-11 PET/computed tomography (CT) findings were investigated. Inclusion criteria included histopathologically proven prostate adenocarcinoma, two consecutive PSA levels > 0.20 ng/mL, and negative CT of the abdomen and pelvis or magnetic resonance imaging of the pelvis and whole-body bone scan. Exclusion criteria were non-prostate malignancy within 3 years and persistent PSA after radical prostatectomy. Patients with findings of recurrent disease on re-staging conventional imaging were excluded, as were patients previously treated with systemic therapy and/ or salvage therapy. 51 patients were enrolled in this study. 34/51 (66.7%) patients had at least one site of 68Ga-PSMA-11 uptake consistent with PCa. 23.5% of patients had recurrence in the prostate bed, 27.4% had pelvic lymph nodes, 15.7% had extrapelvic lymph node metastases, and 17.6% had bone metastases. For patients with lymph node involvement/metastasis, bone metastasis, and patients with both, their median serum PSA levels were 1.83 ng/mL, 2.54 ng/mL, and 4.03 ng/mL, respectively. They were diagnosed with recurrence with a median of 2.06 years, 2.54 years, and 1.15 years after radical prostatectomy, respectively. In this study of Chinese men with biochemical recurrence, added value for the detection of lesions compatible with sites of PCa was found with 68Ga-PSMA-11 PET/CT over conventional imaging. The observed patterns of disease spread may have implications for understanding the biology of early prostate cancer metastasis. Keywords Prostate-specific membrane antigen · Prostate cancer · Biochemical recurrence
Introduction Liang Dong, Yinjie Zhu and Mei Xin contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12032-020-01412-7) contains supplementary material, which is available to authorized users. * Jianjun Liu [email protected] * Wei Xue [email protected] * Steven P. Rowe [email protected] Extended author info rmation available on the last page of the article
Prostate cancer (PCa) continues to be the most common cancer and the second leading cause of cancer death in American men [1]. Approximately, 170,000 new diagnoses of PCa and over 31,000 deaths are estimated to occur annuall
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