The role of ( 68 Ga)PSMA I&T in biochemical recurrence after radical prostatectomy: detection rate and the correlati
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ORIGINAL ARTICLE
The role of (68Ga)PSMA I&T in biochemical recurrence after radical prostatectomy: detection rate and the correlation between the level of PSA, Gleason score, and the SUVmax Ugur Yilmaz1 · Halil Komek2 · Canan Can2 · Serdar Altindag2 Received: 3 March 2019 / Accepted: 28 April 2019 © The Japanese Society of Nuclear Medicine 2019
Abstract Objective The aim of the study was to retrospectively evaluate the recurrence detection rate of Gallium-68-prostate-specific membrane antigen [(68Ga)PSMA] imaging and therapy (I&T) positron emission tomography/computed tomography (PET/ CT) at different PSA levels, which enables early detection of patients with radical prostatectomy. We also aimed to compare Gleason scores, used drugs (LHRH analogs and antiandrogens), PSA levels with SUVmax values, and detection rates. Method This retrospective study included 107 patients who underwent radical prostatectomy and who underwent (68Ga) PSMA I&T PET/CT imaging between January 2015 and December 2018 for the early detection of recurrence. The PSA values, Gleason scores, treatments, lesions detected on (68Ga)PSMA I&T, and S UVmax values were recorded for all patients. Results Patients with a median PSA level of 1.22 ng/mL were divided into seven groups according to the PSA values. The lowest lesion detection rate was found to be 7/16 patients (43.8%) when the PSA was 3.5 ng/ml. There was a positive correlation between PSA level and ppSUVmax (per patient SUVmax) value of the patients with lesions (p
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