Prostate Cancer Cellular and Genetic Mechanisms of Disease Developme
The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-
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Scott M. Dehm Donald J. Tindall Editors
Prostate Cancer
Cellular and Genetic Mechanisms of Disease Development and Progression Second Edition
Advances in Experimental Medicine and Biology Volume 1210
Series Editors Wim E. Crusio, CNRS and University of Bordeaux UMR 5287, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, Pessac Cedex, France John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA Nima Rezaei, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Scott M. Dehm • Donald J. Tindall Editors
Prostate Cancer Cellular and Genetic Mechanisms of Disease Development and Progression Second Edition
Editors Scott M. Dehm Department of Laboratory Medicine and Pathology Department of Urology Masonic Cancer Center University of Minnesota Minneapolis, MN, USA
Donald J. Tindall Departments of Urology, and Biochemistry & Molecular Biology Mayo Clinic College of Medicine Rochester, MN, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-32655-5 ISBN 978-3-030-32656-2 (eBook) https://doi.org/10.1007/978-3-030-32656-2 © Springer Nature Switzerland AG 2013, 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Prostate cancer is the most frequently diagnosed non-cutaneous cancer in men and the second leading cause of male cancer deaths in the United States. The two main risk factors for developing prostate cancer are being male and aging, with additional contributions from genetic and environmental factors. These genetic and environmental factors may also account for disparities
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