DNA Methylation: Development, Genetic Disease and Cancer
It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell typ
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · P.K. Vogt, La Jolla/California H. Wagner, Munich
W. Doerfler and P. Böhm (Eds.)
DNA Methylation: Development, Genetic Disease and Cancer With 25 Figures and 10 Tables
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Prof. Dr. Walter Doerfler Universität zu Köln Institut für Genetik Zülpicher Str. 47 50674 Köln and Institut für Klinische und Molekulare Virologie Universität Erlangen Schlossgarten 4 91054 Erlangen Germany e-mail: walter.doerfl[email protected], walter.doerfl[email protected]
Petra Böhm Universität zu Köln Institut für Genetik Zülpicher Str. 47 50674 Köln Germany e-mail: [email protected]
Cover Illustration: Random distribution of parental chromosomes during somatic cell division. Fluorescence in situ hybridization with differentially labeled centromeric satellite DNAs was used to distinguish between maternal Mus musculus and paternal M. spretus chromosomes in a mouse hybrid metaphase.
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Preface
Volume 301 of Current Topics in Microbiology and Immunology, DNA Methylation: Basic Mechanisms, which was published earlier this year, provided an introduction to the field and summarized ongoing research on elementary mechanisms related to DNA methylation. Due to the delayed ava
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