DNA Methylation: Development, Genetic Disease and Cancer

It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell typ

  • PDF / 2,968,245 Bytes
  • 290 Pages / 439.37 x 666.142 pts Page_size
  • 58 Downloads / 271 Views

DOWNLOAD

REPORT


Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · P.K. Vogt, La Jolla/California H. Wagner, Munich

W. Doerfler and P. Böhm (Eds.)

DNA Methylation: Development, Genetic Disease and Cancer With 25 Figures and 10 Tables

123

Prof. Dr. Walter Doerfler Universität zu Köln Institut für Genetik Zülpicher Str. 47 50674 Köln and Institut für Klinische und Molekulare Virologie Universität Erlangen Schlossgarten 4 91054 Erlangen Germany e-mail: walter.doerfl[email protected], walter.doerfl[email protected]

Petra Böhm Universität zu Köln Institut für Genetik Zülpicher Str. 47 50674 Köln Germany e-mail: [email protected]

Cover Illustration: Random distribution of parental chromosomes during somatic cell division. Fluorescence in situ hybridization with differentially labeled centromeric satellite DNAs was used to distinguish between maternal Mus musculus and paternal M. spretus chromosomes in a mouse hybrid metaphase.

Library of Congress Catalog Number 72-152360 ISSN 0070-217X ISBN-10 3-540-31180-7 Springer Berlin Heidelberg New York ISBN-13 978-3-540-31180-5 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Simon Rallison, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Nadja Kroke, Leipzig Cover design: design & production GmbH, Heidelberg Typesetting: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper SPIN 11536994 27/3150/YL – 5 4 3 2 1 0

Preface

Volume 301 of Current Topics in Microbiology and Immunology, DNA Methylation: Basic Mechanisms, which was published earlier this year, provided an introduction to the field and summarized ongoing research on elementary mechanisms related to DNA methylation. Due to the delayed ava