Proteases In The Brain
In all organs of the body proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative dis
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PROTEASES IN BIOLOGY AND DISEASE SERIES EDITORS: NIGEL M. HOOPER, University of Leeds, Leeds, United Kingdom UWE LENDECKEL, Otto-von-Guericke University, Magdeburg, Germany
Volume 1 PROTEASES IN TISSUE REMODELLING OF LUNG AND HEART Edited by Uwe Lendeckel and Nigel M. Hooper Volume 2 AMINOPEPTIDASES IN BIOLOGY AND DISEASE Edited by Nigel M. Hooper and Uwe Lendeckel Volume 3 PROTEASES IN THE BRAIN Edited by Uwe Lendeckel and Nigel M. Hooper
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
PROTEASES IN THE BRAIN Edited by
Uwe Lendeckel Otto-von-Guericke University Magdeburg, Germany
and
Nigel M. Hooper University of Leeds Leeds, United Kingdom
Springer
eBook ISBN: Print ISBN:
0-387-23101-3 0-387-23100-5
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Preface
This, the third volume in the Proteases in Biology and Disease series, focuses on Proteases in the Brain. In all organs of the body proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer’s, Parkinson’s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumour progression. This volume brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes. The first chapter by Hans-Gert Bernstein reviews the current knowledge about the impact of proteolytic processes in the development and progression of Alzheimer’s disease and whether proteases may be promising new therapeutic targets for the treatment of this fatal disease. In Chapter 2, Stephen Crocker, Patrice Smith and David Park review the current hypotheses about how dopamine neurons of the substantia nigra pars compacta degenerate in Parkinson’s disease, focusing attention on the recent evidence supporting a central role for calcium-dependent calpains in this process. The prominent role of the cysteine proteases of the calpain and caspase families in the pathogenesis of brain ischemia are discussed in Chapter 3 by Swapan Ray. A description of the use of calpain and caspase inhibitors for neuroprotection in brain ischemia is also presented. Multiple proteases, including the calpains, caspases, cathepsins, serine proteases and matrix metalloprotease
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