Proteases in Death Pathways
Caspases are the essential proteases in cellular death pathways and well known as the key players during apoptosis. They are involved in the initiation and execution of the extrinsic and caspase-dependent intrinsic apoptotic pathways as well as in pyropto
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teases: Structure and Function
Proteases: Structure and Function
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Klaudia Brix • Walter Sto¨cker Editors
Proteases: Structure and Function
Editors Klaudia Brix School of Engineering and Science Jacobs University Bremen Germany
Walter Sto¨cker Institute of Zoology Johannes Gutenberg University Mainz Germany
ISBN 978-3-7091-0884-0 ISBN 978-3-7091-0885-7 (eBook) DOI 10.1007/978-3-7091-0885-7 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2013956226 © Springer-Verlag Wien 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
The first chapter “Protease Families, Evolution, and Mechanism of Action” provides us with a comprehensive and refreshing view over protease and peptidase family relationships. It is written by Neil Rawlings, THE expert, when it comes to proteolytic enzyme classification. He has pioneered and initiated with Alan Barrett MEROPS, an invaluable database for protease researchers, that has been maintained and updated for several years now. The first chapter of this book therefore introduces and explains the logics of this exceptional information resource and compendium on proteases. The conclusion of Neil Rawlings’ chapter considers classification based on the comparison o
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