Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model
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Protective Effect of Boric Acid and Omega-3 on Myocardial Infarction in an Experimental Rat Model Hadi Karimkhani 1 Güngör Kanbak 2
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Mete Özkoç 2
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Paria Shojaolsadati 3
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Kubilay Uzuner 4
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Dilek Burukoglu Donmez 5
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Received: 19 May 2020 / Accepted: 25 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Boric acid and omega-3 are used as essential elements for both animal and human health. Many researchers have shown these beneficial effects on cardiac and inflammatory markers. This study aims to evaluate cardiac protective effect of boric acid and omega-3 against MI (myocardial infarction), probably due to the suppression of pro-inflammatory cytokines of natriuretic peptides in rats. Fifty male Sprague-Dawley rats were randomly divided into five groups: control, MI, MI+boric acid, MI+ omega-3, and MI+boric acid+omega-3. Saline solution (2 ml/day), omega-3 (800 mg/kg/day), and boric acid (100 mg/kg/day)+ omega-3 (800 mg/kg/day) were orally administered to the relevant groups throughout the 28 days. To constitute the MI model, the rats were exposed to isoproterenol-HCl (ISO) (200 mg/kg, S.C.) on the 27th and 28th. In the MI group, serum levels of CKMB, BNP, and TNF-α are increased significantly. Also, ST waves and heart rates were higher in the MI than the control. These results demonstrate that biochemical results healed in MI+boric acid, MI+omega-3, and MI+boric acid+omega-3 groups compared MI group. ECG and light microscope results supported the findings as well. The statistical analysis showed that boric acid and/or omega-3 has protective effects on cellular damage in MI. Keywords Myocardial infarction . Boric acid . Omega-3 . Electrocardiography (ECG) . Rat model
Introduction Cardiovascular diseases (CD) are multifactorial diseases which cause 17.3 million deaths per year worldwide and CD-related deaths will affect more than 23.6 million people by 2030. CD is a significant problem related to general health, with poor prognosis [1]. Myocardial infarction (MI) is the
most common type of CD and it has high morbidity and mortality worldwide. MI is identified as an irreversible myocardial disease which is based on necrotic damage of myocyte and it is generally seen in the left ventricle (LV). This damage is caused by inadequate tissue perfusion or prolonged ischemia [2–4].
The study, which was also a doctoral thesis, was presented in 41. FEBS Congress as a poster. * Hadi Karimkhani [email protected] Mete Özkoç [email protected] Paria Shojaolsadati [email protected] Kubilay Uzuner [email protected]
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Department of Biochemistry, School of Medicine, Istanbul Okan University, Istanbul, Turkey
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Department of Biochemistry, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
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Department of Anatomy, School of Medicine, Istanbul Okan University, Istanbul, Turkey
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Department of Physiology, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
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Department of Histology and Embryology, School of Medicine, Eskisehir Osm
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