Protein Structure and Modeling
The volume covers the advances made by the most recent experimental and theoretical research in the structure of the most extensively studied main biological macromolecules - the proteins. Proteins are remarkably regular highly ordered biopolymers. Their
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Protein Structure and Modeling
Protein Structure and Modeling
Natalya Kurochkina
Protein Structure and Modeling
Natalya Kurochkina Department of Biophysics School of Theoretical Modeling Washington, DC, USA
ISBN 978-981-13-6600-0 ISBN 978-981-13-6601-7 https://doi.org/10.1007/978-981-13-6601-7
(eBook)
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Preface
Structure of proteins, nucleic acids, polysaccharides, and lipids is very important for our understanding of biological processes and life functions. Biological macromolecules are very complex objects to study. Proteins represent the largest and most extensively studied group of biopolymers. Comprising thousands of atoms, they exhibit several levels of organization, multiple isoforms, dynamic behavior, and diverse functions. With advancements in sequencing, complete genomes of many organisms are being decoded. We are able to compare healthy and diseased organisms and observe changes during development. These rapid methods bring new data on the basic building blocks of living organisms and allow their thorough comparison and elucidation of principles of organization. X-ray crystallography, NMR, electron microscopy, and other methods reveal structure of macromolecules at atomic resolution which contributes to significant progress in many areas of biomedical research, medicine, biotechnology, and design of new drugs. With growing amount of data, new approaches in biochemistry, mathematics, biophysics, structural biology, and other areas lead to development and refinement of theoretical models. Increase in accuracy and number of experimental and theoretical models help
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