Modeling Peptide-Protein Interactions Methods and Protocols
This volume covers an array of techniques available for studying peptide-protein docking and design. The book is divided into four sections: peptide binding site prediction; peptide-protein docking; prediction and design of peptide binding specificity; an
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Ora Schueler-Furman Nir London Editors
Modeling Peptide-Protein Interactions Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Modeling Peptide-Protein Interactions Methods and Protocols
Edited by
Ora Schueler-Furman Microbiology and Molecular Genetics, Hebrew University Hadassah Medical School, Jerusalem, Israel
Nir London Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
Editors Ora Schueler-Furman Microbiology and Molecular Genetics Hebrew University Hadassah Medical School Jerusalem, Israel
Nir London Organic Chemistry The Weizmann Institute of Science Rehovot, Israel
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6796-4 ISBN 978-1-4939-6798-8 (eBook) DOI 10.1007/978-1-4939-6798-8 Library of Congress Control Number: 2017933836 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover Caption: Peptide docking: Programs such as GalaxyPepDock can generate a refined model (dark green) that is very similar to the native structure (yellow), starting from an initial similar model (green), or even farther. Image courtesy of Hasup Lee and Chaok Seok. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Peptide-mediated interactions play prominent roles in many cellular processes: their weak, transient character, and their easy manipulation by targeted changes such as post-translational modifications, makes them especially amenable to versatile regulation. The structure of a pe
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