Proteostasis and Chaperone Surveillance
Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contr
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teostasis and Chaperone Surveillance
Proteostasis and Chaperone Surveillance
Laishram Rajendrakumar Singh Tanveer Ali Dar • Parvaiz Ahmad Editors
Proteostasis and Chaperone Surveillance
Editors Laishram Rajendrakumar Singh Dr. B. R. Ambedkar Center for Biomedical Research University of Delhi New Delhi, Delhi, India
Tanveer Ali Dar Clinical Biochemistry University of Kashmir Srinagar, Jammu and Kashmir, India
Parvaiz Ahmad Department of Botany University of Kashmir Srinagar, Jammu and Kashmir, India
ISBN 978-81-322-2466-2 ISBN 978-81-322-2467-9 DOI 10.1007/978-81-322-2467-9
(eBook)
Library of Congress Control Number: 2015949224 Springer New Delhi Heidelberg New York Dordrecht London © Springer India 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer (India) Pvt. Ltd. is part of Springer Science+Business Media (www.springer.com)
Preface
Human diseases have been the matter of gravest concern ever since the conception of scientific research. Whether it is basic or applied research, all intend to cater one single curiosity of man, and that is attainment of illnessfree healthy life. Indeed, we are in an era where many of the earlier deadly considered disorders no longer exist, but still we have to cover a very long distance in order to find cure for all. However, in this search we have realized that it is the basic biomolecules that are of esteem importance and has a great deal of involvement in disease development. Protein is one such biomolecule of keen interest for researchers as it is responsible for the ultimate biological function. It is the fine balance of proteostasis inside the cell that is responsible for smooth functioning of various cellular activities, and any lapse in this molecular balance can lead to a fatal disorder. For instance, loss of function of a protein either due to impaired protein synthesis or improper protein folding is known to cause various disorders such as cystic fibrosis, phenylketonuria, etc., and
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