Proton Beam Radiotherapy Physics and Biology
This book offers a comprehensive, practical guide to understanding the physical and biological characteristics of proton beam radiotherapy. The application of proton beams to the treatment of solid cancers has expanded exponentially over the last decade d
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Proton Beam Radiotherapy
Koji Tsuboi • Takeji Sakae Ariungerel Gerelchuluun Editors
Proton Beam Radiotherapy Physics and Biology
Editors Koji Tsuboi University of Tsukuba Proton Medical Research Center Tsukuba, Ibaraki Japan
Takeji Sakae University of Tsukuba Proton Medical Research Center Tsukuba, Ibaraki Japan
Ariungerel Gerelchuluun University of Tsukuba Faculty of Medicine Tsukuba, Ibaraki Japan
ISBN 978-981-13-7453-1 ISBN 978-981-13-7454-8 (eBook) https://doi.org/10.1007/978-981-13-7454-8 © Springer Nature Singapore Pte Ltd. 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
Part I History of Proton Radiotherapy and Overview Discovery of the Proton and Its Intrinsic Powers ������������������������������������������ 3 Kiyoshi Yasuoka Early History of Biology and Clinical Application of Proton Beam Therapy���������������������������������������������������������������������������������������������������� 9 Koji Tsuboi The Current Status of Proton Beam Therapy������������������������������������������������ 23 Yutaro Mori Part II Physical Characteristics of Proton Radiotherapy Physical Characteristics of Proton Beams ������������������������������������������������������ 37 Hideyuki Takei Dosimetry of Proton Beams������������������������������������������������������������������������������ 51 Kiyoshi Yasuoka Track Structure and Microdosimetry of Proton Beams�������������������������������� 61 Tatsuhiko Sato Qualitative Comparison of Proton Beams and Other Radiotherapy Beams������������������������������������������������������������������������������������������ 73 Kenta Takada Part III Equipments and QA of Pr
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