Psoriasis is Associated with a High Comedication Burden: A Population Based Register Study
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ORIGINAL RESEARCH
Psoriasis is Associated with a High Comedication Burden: A Population Based Register Study Albert Duvetorp
. Ulrich Mrowietz . Mats Nilsson .
Oliver Seifert
Received: July 23, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: A large body of evidence supports the association between psoriasis and concomitant diseases. However, the study of
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Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13555020-00442-3) contains supplementary material, which is available to authorized users. A. Duvetorp (&) Division of Dermatology, Ska˚ne University Hospital, ¨ , Sweden Malmo e-mail: [email protected] A. Duvetorp O. Seifert Department of Clinical and Experimental Medicine, ¨ ping Faculty of Medicine and Health Sciences, Linko ¨ ping, Sweden University, Linko U. Mrowietz Psoriasis-Center at the Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany M. Nilsson Futurum-Academy for Health and Care, Region ¨ nko ¨ ping County, Jo ¨ nko ¨ ping, Sweden Jo O. Seifert Division of Dermatology and Venereology, Region ¨ nko ¨ ping County, Jo ¨ nko ¨ ping, Sweden Jo
comedication for these diseases in patients with psoriasis is limited. The current study aimed to investigate the prescription and drug dispensation for comorbidity associated with psoriasis. Methods: We conducted a retrospective casecontrol study from 9 April 2008 until 1 January 2016 using an electronic medical records database covering the entire population of the ¨ nko ¨ ping and the Swedish PreCounty of Jo scribed Drug Register. ICD-10 and Anatomical Therapeutic Chemical codes were used to identify patients with psoriasis and dispensed pharmaceutical prescriptions. Individuals without psoriasis were selected as controls. Patients receiving systemic treatment for psoriasis were considered as having moderatesevere psoriasis. Odds ratios for being dispensed pharmaceutical prescriptions and differences in mean number of dispensed prescriptions were explored. Results: A total of 4587 patients with psoriasis were identified in the medical records, and 268,949 individuals served as controls. Patients with psoriasis had a significantly higher number of different drug dispensations compared to controls. Only 1.3% of all patients with psoriasis were without any prescription (excluding medication for psoriasis) during the study period while the number in the general population was 9.3%. Sex- and age-adjusted odds ratios for dispensation of drug groups related to comorbid disease were significantly higher among patients with psoriasis including drug groups
Dermatol Ther (Heidelb)
such as anxiolytics and sedatives as well as drugs targeting COPD, migraine and erectile dysfunction. The most frequently dispensed comedications were oral antibiotics and analgesics including an increased risk for dispensation of opioids. Sex predisposed dispensation frequency for a
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