High body fat percentage is associated with primary aldosteronism: a cross-sectional study
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(2020) 20:175
RESEARCH ARTICLE
Open Access
High body fat percentage is associated with primary aldosteronism: a crosssectional study Worapaka Manosroi1*
and Pichitchai Atthakomol2
Abstract Background: Excess aldosterone has been shown to be associated with obesity; however, there is currently a lack of data regarding the relationship between percentage of body fat and primary aldosteronism (PA), particularly pertaining to Asian populations. Furthermore, essential hypertension may mimic the condition of PA and there needs to be differentiation between the two. This study aimed to assess the association between percentage of body fat and PA. Methods: A cross-sectional study was conducted in the outpatient department of the Endocrine and Metabolism Unit of the tertiary care medical center in Thailand. Data was obtained from 79 patients who had been screened for PA due to hypertension in young-onset, hypokalemia, adrenal incidentaloma or resistance hypertension. Essential hypertension was defined as patients who had high blood pressure and were negative for PA screening. Body fat percentage was assessed by bioelectrical impedance analysis. The relationship between percentage of body fat and a diagnosis of PA was assessed using logistic regression analysis, including adjustment for confounding factors. Results: The participants were divided into a PA group (n = 41) and an essential hypertension group (n = 38). After controlling for confounding variables (age, sex, body mass index, cholesterol and insulin resistance status), the odds ratio of having PA in males with a percentage of body fat > 25% and females with percentage > 30% was 1.82 (95%CI = 1.79–1.86, p < 0.001). Conclusion: A higher percentage of body fat is associated with an increased risk of PA. Further studies need to be conducted to confirm the relationship between body fat percentage and PA. Keywords: Essential hypertension, Percent body fat, Primary aldosteronism
Background Overweight and obesity have been reported to be strongly associated with hypertension [1]. A strong relationship between body mass index (BMI) and systolic blood pressure/diastolic blood pressure has also been demonstrated [2]. Obesity-related hypertension is considered to be one of the most common forms of * Correspondence: [email protected] 1 Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University Hospital, 110 Intrawarorot Road Soi 2, Si Phum, Amphoe Mueang Chiang Mai, Chiang Mai 50200, Thailand Full list of author information is available at the end of the article
hypertension, although the precise clarification is still inconclusive [3]. Previous studies have suggested that aldosterone may be the culprit in obesity-related hypertension [4, 5]. Aldosterone is a mineralocorticoid hormone mainly produced by the zona glomerulosa in the adrenal cortex. It is a key hormone for maintenance of sodium preservation systems in the kidney [6]. Elevated aldosterone levels have been observed in people with obesity, particulary abdominal ob
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