PVA-BA/PEG hydrogel with bilayer structure for biomimetic articular cartilage and investigation of its biotribological a
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PVA-BA/PEG hydrogel with bilayer structure for biomimetic articular cartilage and investigation of its biotribological and mechanical properties Lingling Cui1, Wei Tong1, Huangjie Zhou1, Chengqi Yan1, Junyue Chen1, and Dangsheng Xiong1,* 1
School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Received: 1 September 2020
ABSTRACT
Accepted: 16 October 2020
Polyvinyl alcohol (PVA) is perceived as a candidate of synthetic articular cartilage, whose real-world applications have been hindered by poor mechanical and biotribological properties. One-step gelation method was used herein for the synthesis of a biomimetic PVA-BA/PEG hydrogel with porous bilayer structure. Importantly, two layers were integrated closely and both showed porous network. The upper layer of this hydrogel could show high compressive tangent modulus to resist deformation during friction; in the meantime, its bottom layer was able to prevent the leakage of interstitial water and increase the consumption of load. Due to porous high-water-content hydrogel bulk inside bottom layer, this cast-dry PVA-BA/PEG hydrogel could show close to 70% of water-retention capacity. On the other hand, the complexation of BA and PVA greatly strengthened the stability of the polymer network for the PVA-BA/ PEG hydrogel. Therefore, the PVA-BA/PEG hydrogel could achieve an excellent combination of high mechanical properties and low friction coefficient. When the addition of BA was 1.4 wt %, the tensile strength of the PVA-BA/PEG hydrogel reached 4.41 MPa at an elongation of 573% and its compressive tangent modulus was 4.6 MPa at a strain of 60%. The COF of the hydrogel under water lubrication or calf serum was very low even at a high load, which is of high application potential for the articular cartilage repair.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Handling Editor: Jaime Grunlan. Lingling Cui, Wei Tong and Huangjie Zhou have contributed equally to the study.
Address correspondence to E-mail: [email protected]
https://doi.org/10.1007/s10853-020-05467-9
J Mater Sci
Introduction Articular cartilage, as a viscoelastic connective tissue in the joint, is able to provide efficient aqueous lubrication and mechanical support. Once damaged or injured, cartilage is difficult to be repaired itself due to its avascular nature and limited healing capabilities [1–3]. Hydrogel is expected to be an ideal material for cartilage replacement because of its physiochemical similarity to articular cartilage [4, 5]. Thus, an increasing number of researchers have focused on the fabrication of porous hydrogel materials to repair cartilage defects [6]. Among the research community, lubrication and mechanical properties are major concerns as they are highly related to the comfort level of patients during implantation. So far, polyvinyl alcohol (PVA) is trend as a candidate of synthetic articular cartilage due to excellent properties such as biocompatible, chemical resistance and low protein adsorptio
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