204 Magnetic resonance imaging findings in early arrhythmogenic right ventricular dysplasia
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Meeting abstract
204 Magnetic resonance imaging findings in early arrhythmogenic right ventricular dysplasia Aditya Jain*, Harikrishna Tandri, Jens Vogel-Claussen, Harjit Chahal, Hugh Calkins and David A Bluemke Address: Johns Hopkins University, Baltimore, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A65
doi:10.1186/1532-429X-10-S1-A65
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A65 © 2008 Jain et al; licensee BioMed Central Ltd.
Introduction Magnetic resonance (MR) imaging is readily applied for the diagnosis of advanced structural abnormalities associated with arrhythmogenic right ventricular dysplasia (ARVD). However, the earliest morphologic or functional abnormalties in ARVD on MR imaging have not been previously described.
Purpose To describe MRI findings in phenotypically confirmed cases of ARVD with negative or borderline MRI diagnosis.
Methods The Multidisciplinary Study of Right Ventricular Dysplasia aims to characterize the clinical and genetic aspects of ARVD. As of September 2007, 87 newly diagnosed probands were enrolled and phenotyped as affected following the results of invasive and non-invasive tests and based on the task force criteria. MRI was performed in 73 patients (84%) according to a standard protocol at enrollment. During enrollment the MRI was anonymized and interpreted by the core lab in a blinded fashion and categorized as affected, unaffected or borderline. Phenotyping was performed by the PI based on the results of invasive and non-invasive evaluation. Following the final phenotype, MR images of ARVD probands that were initially classified as borderline or unaffected by the corelab were reanalyzed to determine early structural alterations in ARVD. Patients with borderline or unaffected MR imaging diagnosis were compared with patients with definite MR
imaging diagnosis of ARVD using Student's unpaired ttest.
Results Of the 73 patients enrolled and phenotyped as ARVD, 35 (48%) were classified on MR imaging as affected (group 1) and 30 (group 2) were classified as either borderline (n = 18, 25%) or unaffected (n = 12, 16%). The remaining 8 (11%) had uninterpretable MRI examinations. RV enddiastolic volume, end-diastolic diameter and RV outflow tract area were significantly higher and RV ejection fraction was lower in group 1 compared to group 2 (table in Figure 1). No differences were detected in left ventricular volumes and dimensions. RV ejection fraction and atrial diameter were significantly worse in patients with borderline ARVD diagnosis on MR imaging compared with the unaffected at P < 0.05 significance level. Qualitative MR imaging abnor
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