3.7 Hypertension and Impaired Carbohydrate Tolerance
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Epidemiology 3.7 Hypertension and Impaired Carbohydrate Tolerance E. Colli (1), R. Pedrazzoli (1), S. Onolfo (1), E. Scaglia (1), G.P. Carnevale Schianca (1), E. Bartoli (1) ` Piemonte Orientale, Ospedale Maggiore, Novara, Italy (1)Universita Introduction. Patients suffering from hypertension and patients with type 2 diabetes exhibit a high cardiovascular risk. Moreover, hypertension alone doubles the risk of developing diabetes. In this study we examined impaired carbohydrates tolerance (ICT) in a group of subjects whose fasting plasma glucose (FPG) was less than 125 mg/dl. Methods. We recruited 721 subjects (aged 53.2 ±12.7; 341 male and 380 female) studied by OGTT and classified as normo-gluco-tolerant (NGT) if FPG 140 mg/dl. These subjects were divided into four groups depending on the duration of hypertension: 1-5 years (group A), 6-10 years (group B), 11-15 years (group C), more than 15 years (group D). Results. Group A includes 445 subjects, 58,4% NGT and 41,6 % ITC. Group B includes 119 subjects, 52,1% NGT and 47,9% ICT. Group C includes 82 subjects, 40,2% were NGT and 59,8% ICT. Group D includes 75 subjects, 33,3% NGT and 66,7% ICT. The percentage of NGT subjects decreases gradually with the progressive prolongation of the duration of hypertension whilst the opposite trend is displayed by ICT, the percentage of which rises progressively (X2= 22.2, p < 0.0007). It is important to notice that a larger percentage of hypertensive patients (41,6%) suffers from ICT at the beginning of their disease. Since the age of our population rises with the duration of hypertension, we performed the ANOVA analysis to estimate the importance of age: this variable does not influence the comparison between group B and C (p = 0.52) and between C and D (p = 0.17). Restricting our analysis to subjects aged
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