9.20 Hypertension, Obesity and Vascular and Renal Damage
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Metabolic Aspects and Mechanisms 9.20 Hypertension, Obesity and Vascular and Renal Damage N. Conti (1), F. Viazzi (1), G. Leoncini (1), E. Ratto (1), E. Baratto (1), G. Adami (2), F.S. Papadia (2), G. Deferrari (1), R. Pontremoli (1) ` San Martino, Genova; (2)Dipartimento di (1)Azienda Ospedale Universita Discipline chirurgiche, morfologiche e Metodologie integrate (DICMI), Genova, Italy Introduction. Hypertension and obesity, are well known, highly prevalent risk factors for cardiovascular (CV) disease. In both conditions, the occurrence of acute events is often preceded and predicted by the onset (presence) of subclinical organ (vascular) damage(OD). Aim. To investigate the prevalence and clinical correlates of vascular and renal damage in patients with and without obesity and hypertension. Methods. A group of 164 white, obese patients referred for surgical treatment of obesity and an ageand gender-matched group of 164 non-obese, hypertensive patients were studied. Renal and vascular organ damage was assessed by albuminuria (albumin to creatinine ratio on three non consecutive first morning urine samples) and carotid US scan, respectively. Results. On the basis of presence/absence of hypertension and obesity, we identified three subgroups of patients: non obese hypertensive (n= 164), obese normotensive (n= 87), and obese hypertensive patients (n= 77). There was a significant trend toward higher ACR values and greater carotid intimamedia thickening along (in) the three subgroups (P
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