A comparison of gene expression profiles in patients with coronary artery disease, type 2 diabetes, and their coexisting
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RESEARCH
Open Access
A comparison of gene expression profiles in patients with coronary artery disease, type 2 diabetes, and their coexisting conditions Rui Gong1, Menghui Chen2, Cuizhao Zhang3, Manli Chen1 and Haibin Li4*
Abstract Background: To support a hypothesis that there is an intrinsic interplay between coronary artery disease (CAD) and type 2 diabetes (T2D), we used RNA-seq to identify unique gene expression signatures of CAD, T2D, and coexisting conditions. Methods: After transcriptome sequencing, differential expression analysis was performed between each disordered state and normal control group. By comparing gene expression profiles of CAD, T2D, and coexisting conditions, common and specific patterns of each disordered state were displayed. To verify the specific gene expression patterns of CAD or T2D, the gene expression data of GSE23561 was extracted. Results: A strong overlap of 191 genes across CAD, T2D and coexisting conditions, were mainly involved in a viral infectious cycle, anti-apoptosis, endocrine pancreas development, innate immune response, and blood coagulation. In T2D-specific PPI networks involving 64 genes, TCF7L2 (Degree = 169) was identified as a key gene in T2D development, while in CAD-specific PPI networks involving 64 genes, HIF1A (Degree = 124), SMAD1 (Degree = 112) and SKIL (Degree = 94) were identified as key genes in the CAD development. Interestingly, with the provided expression data from GSE23561, the three genes were all up-regulated in CAD, and SMAD1 and SKIL were specifically differentially expressed in CAD, while HIF1A was differentially expressed in both CAD and T2D, but with opposite trends. Conclusions: This study provides some evidences in transcript level to uncover the association of T2D, CAD and coexisting conditions, and may provide novel drug targets and biomarkers for these diseases. Keywords: Type 2 diabetes, Coronary artery disease, Gene expression profile
Background Type 2 diabetes (T2D) and coronary artery disease (CAD) often coexist and cause substantial public health and economic burden world-wide. CAD has long been established as a complication of T2D. The plaque formation in T2D patients may narrow the coronary arteries and thus predispose the occurrence of heart attack. It is assumed that there is an intrinsic interplay between T2D and CAD, in the form of shared etiology and pathophysiological mechanisms. The two diseases have shared * Correspondence: [email protected] 4 Department of Cardiology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei province 050051, China Full list of author information is available at the end of the article
common risk factors such as, age, gender, anthropometric, metabolic, socioeconomic and lifestyle variables, as well as psychosocial stress and environmental pollutant exposure. In addition, both diseases are characterized by a chronic inflammatory process [1, 2] and disorders of the coagulation system [3]. T2D has been associated with increased risk of cardiovascular disease and d
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