A comparison of ventilation with a non-invasive ventilator versus standard O 2 with a nasal cannula for colonoscopy with
- PDF / 791,843 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 48 Downloads / 179 Views
ORIGINAL RESEARCH
A comparison of ventilation with a non‑invasive ventilator versus standard O2 with a nasal cannula for colonoscopy with moderate sedation using propofol Mike Fogarty1 · Joseph A. Orr1 · Derek Sakata2 · Lara Brewer1 · Ken Johnson2 · John C. Fang3 · Kai Kuck1 Received: 11 July 2019 / Accepted: 17 November 2019 © Springer Nature B.V. 2019
Abstract The aim of this study was to test the effects of CPAP on moderately sedated patients undergoing colonoscopy. Our hypothesis was that CPAP can reduce the incidence and duration of obstructive apnea and hemoglobin oxygen desaturation in patients undergoing procedural sedation for colonoscopy. Two groups of consenting adult patients scheduled to undergo routine colonoscopy procedures and sedated with propofol and fentanyl were monitored in this study: control and intervention. Patients in the intervention group were connected via a facemask to a ventilator that delivered supplemental oxygen (100%) through a standard air-cushion mask. The mask had a built-in leak to facilitate CO2 clearance during CPAP. Patients in the control group received 2–10 L/min of oxygen via nasal cannula or non-rebreather mask. Subjects in the control group were collected in a prior study and used as historical controls. The primary outcome measures were the number of apneic events and the cumulative duration of apneic events. An apneic event was defined as a period longer than 10 s without respiration. The secondary outcome was the area under the curve (AUC) for the arterial oxygen saturation less than 90% versus time during sedative and analgesic administration (time (s) below threshold multiplied by percent below threshold). A desaturation event was defined as a period of time during which arterial oxygen saturation was less than 90%. 29 patients were enrolled in the intervention group and 156 patients were previously enrolled in the control group as part of an earlier study. The median number of apneic events in the control group was 7 compared to 0 in the intervention group. The intervention group experienced apnea less than 1% of the total procedure time compared to 17% in the control group (p
Data Loading...
