A Method for Generating an Aerosol of the Antibacterial Medicine Cefazolin
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TICAL INSTRUMENTATION
A Method for Generating an Aerosol of the Antibacterial Medicine Cefazolin A. A. Bazhinaa, b, S. V. Valiulina, b, *, A. M. Baklanova, S. N. Dubtsova, S. V. An’kova, c, M. E. Plokhotnichenkoa, T. G. Tolstikovaa, c, and A. A. Onischuka, b aVoevodsky
Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia b Novosibirsk State Pedagogical University, Novosibirsk, 630126 Russia c Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia *e-mail: [email protected] Received January 14, 2020; revised January 14, 2020; accepted April 17, 2020
Abstract—A method for generating cefazolin aerosol particles with sizes from 80 to 1400 nm is presented. By an example of pulmonary administration of the aerosol on laboratory animals (mice), it is shown that this cefazolin delivery technique is close in efficiency to intravenous injection. Keywords: nanoparticles, aerosol, pulmonary administration, cefazolin, antibiotic DOI: 10.1134/S1024856020050048
INTRODUCTION At present, inhalation therapy is used in the treatment of upper respiratory tract diseases, such as asthma, chronic obstructive lung disease, and bronchitis. Inhalation of aerosol particles of drug substances can be used for administration of topical and systemic agents [1, 2]. An advantage of inhalation delivery over oral delivery for systemic agents is exclusion of the substance loss in the gastrointestinal tract and in the process of metabolism, during the first passage through the liver. This allows one to use lesser doses of the substance and, therefore, to moderate side effects. In contrast to injection administration, inhalation therapy is a noninvasive method releasing the patient from the sense of discomfort and necessity of special care by the medical staff in the hospital. However, introduction of new formulations requires a series of investigations including the development of the method for generating the aerosol with the necessary range of particle sizes and stable density and then preclinical and clinical testing. This work is devoted to the development of the method for generating the aerosol of antibacterial medicine cefazolin which is usually used as an injectable preparation [3] used in the treatment of some infectious diseases, including respiratory tract infections. When administered orally, cefazolin is destroyed under the action of the acid medium of the stomach. Using the aerosol form of this substance can allow one to increase the efficiency of its use under the action on
the target organ (lungs) and to introduce the preparation noninvasively, without special medical care and discomfort in the patient. The work demonstrates the working capacity of the method of cefazolin aerosol generation and possibility of its use via inhalation. EXPERIMENTAL TECHNIQUE The scheme of the experimental setup for cefazolin aerosol generation is presented in Fig. 1. The main block of the aerosol generator is
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