A Mixed-ligand Pb(II)-coordination Polymer: Photocatalytic Performance and Reduction Activity of the Inflammatory Respon
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ORIGINAL ARTICLE
A Mixed-ligand Pb(II)-coordination Polymer: Photocatalytic Performance and Reduction Activity of the Inflammatory Response After Severe Burns by Inhibiting NF-κB Signaling Pathway Ruichun Liao 1 & Ji Yan 2
&
Yuejing Xu 3
Received: 16 September 2020 / Accepted: 12 November 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Via the employment of a mixed-ligand method, a novel Pb(II)-coordination polymer with the chemical formula of [Pb(pdc)(bdc)]·2DMF (1, H2bdc = 1,4-benzenedicarboxylic acid and H2pdc = 3,5-pyridinedicarboxylic acid) has been produced via reaction of Pb(NO3)2 with the two organic linkers in a mixed solvent of DMF and water. Complex 1 has high photocatalytic degradation efficiency for methylene blue and rhodamine B under ultraviolet light irradiation. The mechanism of photocatalysis was hypothesized and verified in detail by the r photocatalysis reaction in the existence of the hydroxyl radical scavenger mannitol. Furthermore, the influence of the inflammatory response in the severe burns rats was evaluated. Firstly, the inflammatory response levels were assessed by measuring the content of IL-6 and TNF-α in the plasma after treated with compound. Next, the real time RT-PCR was carried out to determine the signaling pathway of NF-κB relative expression in inflammatory cells. Keywords Coordination polymer . Photocatalytic efficiency . Severe burns
Introduction Shock and bacterial infection caused by severe burns can activate inflammatory cells such as macrophages, neutrophils in the body, which could lead to the generation and release of a large number of cytokines [1]. It is also considered to be an important pathogenesis of SIRS after burns, and it is also the main cause of burn death. The occurrence and development of the inflammatory response after burns mainly depend on the results of a series of chain reactions produced by a variety of inflammatory cytokines [2] Low concentrations of inflammatory cytokines play a protective role, but persistently high concentrations of cytokines can
* Ji Yan [email protected] 1
College of Medicine, Nanchang University, Nanchang, Jiangxi, China
2
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
3
The Life science College of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China
destroy immune functions and cause excessive systemic inflammatory responses [3]. Recent studies have shown that Interleukins IL-8, IL-6, IL-2, tumor necrosis factor-α (TNF-α) as well as other inflammatory cytokines show changes from the first day to the third day after injury rapidly increased and reached or close to the peak [4]. In recent years, coordination polymers (CPs) have become excellent functional materials due to their topological diversities, and potential applications in gas separation and adsorption, photoluminescence, catalysis, and drug delivery and so on [5–10]. These multi-purpose applications are related to their structural characteristics directly. However, t
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