A network pharmacology study on analgesic mechanism of Yuanhu-Baizhi herb pair
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(2020) 20:284
BMC Complementary Medicine and Therapies
RESEARCH ARTICLE
Open Access
A network pharmacology study on analgesic mechanism of Yuanhu-Baizhi herb pair Bobin Mi1, Qiushi Li2, Tong Li3, Jessica Marshall4 and Jiayang Sai1,3*
Abstract Background: Millions of people are suffering from chronic pain conditions, such as headache, arthritis, cancer. Apart from western medicines, traditional Chinese medicines are also well accepted for pain management, especially in Asian countries. Yuanhu-Baizhi herb pair (YB) is a typical herb pair applied to the treatment of stomach pain, hypochondriac pain, headache, and dysmenorrhea, due to its effects on analgesia and sedation. This study is to identify potentially active compounds and the underlying mechanisms of YB in the treatment of pain. Methods: Compounds in YB were collected from 3 online databases and then screened by bioavailability and drug likeness parameters. Swiss target prediction was applied to obtain targets information of the active compounds. Pain-related genes were conducted for Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Protein-protein interaction (PPI) networks of the genes were constructed using Cytoscape software. In addition, the hub genes were screened using maximal clique centrality (MCC) algorithm. Results: In total, 31 compounds from Yuanhu were screened out with 35 putative target genes, while 26 compounds in Baizhi with 43 target genes were discovered. Hence, 78 potential target genes of YB were selected for further study. After overlap analysis of the 78 genes of YB and 2408 pain-associated genes, we finally achieved 34 YB-pain target genes, as well as 10 hub genes and 23 core compounds. Go enrichment and KEGG pathway analysis indicated that YB had a strong integration with neuro system, which might significantly contribute to antinociceptive effect. Conclusion: Our data provide deep understanding of the pharmacological mechanisms of YB in attenuating pain. The discovery shed new light on the development of active compounds of YB for the treatment of pain. Keywords: Rhizoma Corydalis, Radix angelicae dahuricae, Pain, Analgesic, Network pharmacology
Background Pain is a common syndrome related to various diseases, such as cancer, fracture, etc. It is estimated that 20% of individuals around the worldwide have some degree of chronic pain [1]. Adequate pain assessment and rational management are essential to improve the quality * Correspondence: [email protected] 1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 3 Department of oncology, The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China Full list of author information is available at the end of the article
of life in this population. Although stepwise escalation of analgesic therapy (paracetamol, non-steroidal antiinflammatory drugs, mild to strong opioids) according to the World Health Organization’s three-step pain ladde
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