A novel time-varying modeling and signal processing approach for epileptic seizure detection and classification
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ORIGINAL ARTICLE
A novel time-varying modeling and signal processing approach for epileptic seizure detection and classification Qinghua Wang1 • Hua-Liang Wei2
•
Lina Wang1
•
Song Xu1
Received: 22 March 2020 / Accepted: 2 September 2020 Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract Electroencephalogram (EEG) signal analysis plays an essential role in detecting and understanding epileptic seizures. It is known that seizure processes are nonlinear and non-stationary, discriminating between rhythmic discharges and dynamic change is a challenging task in EEG-based seizure detection. In this paper, a new time-varying (TV) modeling framework, based on an autoregressive (AR) model structure, is proposed to characterize and analyze EEG signals. The TV parameters of the AR model are approximated through a multi-wavelet basis function expansion (MWBF) approach. An effective ultra-regularized orthogonal forward regression (UROFR) algorithm is employed to significantly reduce and refine the resulting expanded model. Given a time-varying process, the proposed TVAR–MWBF–UROFR method can generate a parsimonious TVAR model, based on which a high-resolution power spectrum density (PSD) estimation can be obtained. Informative features are then defined and extracted from the PSD estimation. The TVAR–MWBF–UROFR method is applied to a number of real EEG datasets; features obtained from these datasets are then used for seizure detection and classification. To make the results more accurate and reliable, a PCA algorithm is adopted to select the optimal feature subset, and a Bayesian optimization technique based on the Gaussian process is performed to determine the coefficients associated with each of the classifiers. The performance of the proposed method is tested on two benchmark datasets, and the experimental results indicate that TVAR–MWBF–UROFR outperforms the compared state-of-the-art classifiers in terms of accuracy, specificity, sensitivity and robustness. Keywords Electroencephalogram (EEG) Epileptic seizure detection Time-varying process Ultra-regularized orthogonal forward regression (UROFR) Time–frequency analysis Bayesian optimization
1 Introduction
Qinghua Wang and Hua-Liang Wei have contributed equally to this work. & Lina Wang [email protected] Qinghua Wang [email protected] Hua-Liang Wei [email protected] 1
National Key Laboratory of Science and Technology on Aerospace Intelligence Control, Beijing Aerospace Automatic Control Institute, Beijing, China
2
Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK
Epilepsy is a widespread and high-risk chronic disease [1]. The pathological cause of epilepsy in individuals is generally unexplained, and the mechanisms behind seizure remain unknown [2]. The prevalence of epilepsy worldwide can be as high as 5% of the general population, and approximately 80% of the people who have epilepsy are in developing countries [3]. EEG signal cont
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