A patent review on strategies for biological control of mosquito vector
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(2020) 36:187
REVIEW
A patent review on strategies for biological control of mosquito vector Kashmira Parihar1 · Manasi Telang1 · Ankita Ovhal1 Received: 15 September 2020 / Accepted: 7 November 2020 © Springer Nature B.V. 2020
Abstract Mosquitoes are the vectors responsible for transmitting serious and life-threatening diseases such as malaria, dengue, yellow fever, chikungunya and lymphatic filariasis. Very few effective vaccines or drugs have been developed so far to prevent or treat these diseases, highlighting a need for vector control. This paper presents a comprehensive technology overview of patent documents disclosing biological agents for mosquito control. The patent analysis revealed that comparable number of patent documents were filed in two technology categories: non-recombinant agents and genetically modified (GM) agents. In the category of non-recombinant agents, toxic peptides from microbes and biological consortia seemed to be the earliest technology noted right from the year 1965 whereas the patent filings for suppression of mosquito population using genetic modification techniques have emerged from the year 2000 onwards. The United States of America is the leading patent filing jurisdiction followed by China and the Great Britain. Academic institutes have filed higher number of patent applications as compared to private companies. University of Florida was found to be the leading patent filing entity and its patents were focused on suppression of vector population using techniques such as release of insects with dominant lethal (RIDL) and RNA interference (RNAi). Keywords Biocontrol · Genetic modification · Mosquito vector · Patent landscape Abbreviation RIDL Release of insect with dominant lethal RNAi Ribo Nucleic Acid interference TMOF Trypsin Modulating Oostatic Factor IPC International Patent Classification CPC Cooperative Patent Classification dsRNA Double stranded RNA ATCC American Type Culture Collection NCIMB National Collection of Industrial, Food and Marine Bacteria NRRL Northern Regional Research Laboratory IIT Incompatible Insect Technique CRISPR Clustered regularly interspersed short palindromic repeats
* Manasi Telang [email protected] 1
Council of Scientific and Industrial Research-Unit for Research and Development of Information Products (CSIR-URDIP), Survey Number 113, 114, NCL Estate, Dr. Homi Bhabha Road, Pashan, Pune 411008, India
Introduction Vector borne diseases account for more than 7,00,000 deaths globally every year and may be caused by parasitic, bacterial and viral infections (WHO- vector-borne-diseases, 2020). Mosquitoes are one of the most important insect vectors responsible for transmitting various pathogens to humans. Female mosquitoes feed on the blood of humans as a source of nutrition to complete their lifecycle. They are instrumental in transmitting pathogens when they suck blood of an infected human and then bite another healthy individual. Numerous mosquito genera spread human diseases. Aedes mosquitos are responsible for the tran
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