A study of MRI-based radiomics biomarkers for sacroiliitis and spondyloarthritis
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ORIGINAL ARTICLE
A study of MRI‑based radiomics biomarkers for sacroiliitis and spondyloarthritis Ariane Priscilla Magalhães Tenório1 · Matheus Calil Faleiros1 · José Raniery Ferreira Junior1 · Vitor Faeda Dalto1 · Rodrigo Luppino Assad1 · Paulo Louzada‑Junior1 · Hiroyuki Yoshida2 · Marcello Henrique Nogueira‑Barbosa1 · Paulo Mazzoncini de Azevedo‑Marques1 Received: 2 December 2019 / Accepted: 17 June 2020 © CARS 2020
Abstract Purpose To evaluate the performance of texture-based biomarkers by radiomic analysis using magnetic resonance imaging (MRI) of patients with sacroiliitis secondary to spondyloarthritis (SpA). Relevance: The determination of sacroiliac joints inflammatory activity supports the drug management in these diseases. Methods Sacroiliac joints (SIJ) MRI examinations of 47 patients were evaluated. Thirty-seven patients had SpA diagnoses (27 axial SpA and ten peripheral SpA) which was established previously after clinical and laboratory follow-up. To perform the analysis, the SIJ MRI was first segmented and warped. Second, radiomics biomarkers were extracted from the warped MRI images for associative analysis with sacroiliitis and the SpA subtypes. Finally, statistical and machine learning methods were applied to assess the associations of the radiomics texture-based biomarkers with clinical outcomes. Results All diagnostic performances obtained with individual or combined biomarkers reached areas under the receiver operating characteristic curves ≥ 0.80 regarding SpA related sacroiliitis and and SpA subtypes classification. Radiomics texture-based analysis showed significant differences between the positive and negative SpA groups and differentiated the axial and peripheral subtypes (P
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