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Ultrasonography (US) is the most accurate tool for exploring cervical lymph nodes for persistent/recurrent lesions in patients with papillary thyroid cancer (PTC). Although certain features are highly informative for malignancy (e.g., the presence of punc

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Thyroid Cancer

Giorgio Grani  •  David S. Cooper Cosimo Durante Editors

Thyroid Cancer A Case-Based Approach Second Edition

Editors Giorgio Grani Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy Cosimo Durante Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy

David S. Cooper Division of Endocrinology, Diabetes, and Metabolism The Johns Hopkins University School of Medicine Baltimore, MD USA

ISBN 978-3-030-61918-3    ISBN 978-3-030-61919-0 (eBook) https://doi.org/10.1007/978-3-030-61919-0 © Springer Nature Switzerland AG 2016, 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface to the Second Edition

There have been few instances in the field of thyroidology as startling and dramatic as the epidemic of differentiated thyroid cancer in virtually all developed and developing countries around the world. Whether this is due, as many suspect, to increases in radiologic procedures and screening, or to environmental factors, such as radiation, or both, continues to be a matter of intense debate. However, for the clinicians caring for the large number of new and prevalent thyroid cancer patients, there is no debate about the need for current, practical, and evidence-based information on management. This is especially the case for our patients with low-risk papillary thyroid cancer, who represent the vast majority of thyroid cancer patients in the twenty-first century. In this group, we are learning that “less is more” in terms of the traditional treatments of surgery, radioiodine, and thyroxine suppressive therapy. Also, the need for immediate biopsy (and surgery) in the case of small, subcentimeter, lo