Adherence to the EAU Guideline Recommendations for Local Tumor Treatment in Penile Cancer: Results of the European PROsp
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ORIGINAL RESEARCH
Adherence to the EAU Guideline Recommendations for Local Tumor Treatment in Penile Cancer: Results of the European PROspective Penile Cancer Study Group Survey (E-PROPS) Maximilian Pallauf
. Marie C. Hempel
. Marie C. Hupe . Matthias May . Marlene Haccius .
Dorothea Weckermann . Steffen Lebentrau . Bernd Hoschke . Ulrike Necknig . Jesco Pfitzenmaier . ¨ rzso ¨ k . Lukas Lusuardi . Axel S. Merseburger Lukas Manka . Philipp Nuhn . Peter To Received: August 14, 2020 / Accepted: September 23, 2020 / Published online: October 10, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Penile cancer (PeCa) is an orphan disease in European countries. The current guidelines are predominantly based on retrospective studies with a low level of evidence. In
Maximilian Pallauf and Marie C. Hempel both contributed equally to this work and should be considered shared first authors. ¨ rzso ¨ k L. Lusuardi M. Pallauf P. To Department of Urology, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria M. C. Hempel (&) M. C. Hupe A. S. Merseburger Department of Urology, University Hospital ¨ beck, Lu ¨ beck, Schleswig-Holstein, Campus Lu Germany e-mail: [email protected] M. May M. Haccius Department of Urology, St. Elisabeth-Hospital Straubing, Straubing, Germany D. Weckermann Department of Urology, University Hospital Augsburg, Augsburg, Germany S. Lebentrau Department of Urology, Brandenburg Medical School Theodor Fontane, Ruppiner Kliniken, Neuruppin, Germany
our study, we aimed to identify predictors for guideline-conform treatment and hypothesize that reference centers for PeCa and physicians’ experience promote guideline compliance and therefore correct local tumor therapy. Methods: This study is part of the European PROspective Penile Cancer Study (E-PROPS), an international collaboration group evaluating therapeutic management for PeCa in Central Europe. For this module, a 14-item-survey was developed and sent to 681 urologists in 45 European centers. Three questions focused on
B. Hoschke Department of Urology, Carl-Thiem-Clinic Cottbus, Cottbus, Germany U. Necknig Department of Urology and Pediatric Urology, Garmisch-Partenkirchen Medical Center, GarmischPartenkirchen, Germany J. Pfitzenmaier Department of Urology, Evangelical Hospital Bethel, Bielefeld, Germany L. Manka Clinic of Braunschweig, Braunschweig, Germany P. Nuhn Department of Urology, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Adv Ther (2020) 37:4969–4980
4970
therapeutic decisions for PeCa in clinical stage Tis, Ta-T1a, and T1b. Four questions addressed potential personal confounders. Survey results were analyzed by bootstrap-adjusted stepwise multivariate linear regression analysis to identify predictors for EAU guideline-conform local treatment of PeCa. Results: For local therapy of cTis 80.4% recommended guideline-conform treatment, for cTa-cT1a 87.3% and for cT1b 59.1%. In total, 42.4% chose a correct approach in all tumor stages. The num
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