Altered inter-hemispheric communication of default-mode and visual networks underlie etiology of primary insomnia
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ORIGINAL RESEARCH
Altered inter-hemispheric communication of default-mode and visual networks underlie etiology of primary insomnia Altered inter-hemispheric communication underlie etiology of insomnia Xi-Jian Dai 1 & Bi-Xia Liu 2 & Sizhi Ai 3 & Xiao Nie 4 & Qiang Xu 1 & Jianping Hu 1 & Qirui Zhang 1 & Yin Xu 1 & Zhiqiang Zhang 1 & Guangming Lu 1
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract To identify altered inter-hemispheric communication between patients with primary insomnia (PIs) and good sleepers (GSs), and their relationships with sleep and emotion-related parameters. Forty-eight PIs and 48 status-matched GSs were asked to complete a number of sleep and emotion-related questionnaires. Voxel-mirrored homotopic connectivity(VMHC) and seed-based functional connectivity were used to characterize the inter-hemispheric coordination. Seven PIs were examined twice to evaluate the test-retest reliability. Support vector machine and ROC curve were applied to discriminate the two groups. Pearson correlation and mediating causality analysis were used to describe the relationships between insomnia-related brain networks and sleep/emotion-related parameters. High test-retest stability (intraclass correlation coefficient ≥ 0.8) of the VMHC maps was observed. Intra-, and inter-hemispheric coordination dysfunctions of the default mode network, visual pathways and executive control network were found. These differences received good discriminatory power to distinguish the two groups (AUC, 0.887; sensitivity, 81.3%; specificity, 87.5%). Intra-, and inter-hemispheric communication within the default mode network and visual pathways correlated with and partially mediated the insomnia-related parameters, while the executive control network correlated with post-insomnia negative emotions. Altered inter-hemispheric coordination within the default mode network and visual pathway may be identified as core predisposing or perpetuating factors in the etiology of PIs, while the executive control network may underlie the post-insomnia negative emotional symptoms. These findings may suggest that the inter-hemispheric communication might be potential neuroimaging markers to discribe underlie neurobiological mechanism of PIs and expand our understanding of the etiology of PIs. Keywords Insomnia . Voxel-mirrored homotopic connectivity . Machine learning classication . Functional connectivity . Visual pathway . Executive control network . Default mode network
Xi-Jian Dai and Bi-Xia Liu contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11682-019-00064-0) contains supplementary material, which is available to authorized users. * Zhiqiang Zhang [email protected]
2
Department of Intensive Care Unit, Jiangxi Provincial Cancer Hospital, Nanchang 330029, Jiangxi, People’s Republic of China
* Guangming Lu [email protected]
3
Department of Cardiology, Heart Center, Henan Key Laboratory of Neurorestoratology, The First A
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