Alternating Electric Fields Therapy in Oncology A Practical Guide to
This concise text provides a complete overview of alternating electric fields therapy -- also known as tumor treating fields -- for glioblastoma and other types of solid tumor malignancies. Readers are given a fundamental understanding of this novel anti-
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Alternating Electric Fields Therapy in Oncology
Eric T. Wong Editor
Alternating Electric Fields Therapy in Oncology A Practical Guide to Clinical Applications of Tumor Treating Fields
Editor Eric T. Wong Division of Neuro-Oncology Department of Neurology Beth Israel Deaconess Medical Center Boston, MA, USA
ISBN 978-3-319-30574-5 ISBN 978-3-319-30576-9 DOI 10.1007/978-3-319-30576-9
(eBook)
Library of Congress Control Number: 2016953732 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
“Questioning our own beliefs in this way (…challenging our assumptions…) isn’t easy, but it is the first step in forming new, hopefully more accurate, beliefs.” Duncan J. Watts in Everything is Obvious
When Mike Ambrogi from Novocure sat down in my office for the first time in 2006 showing me a time-lapse video, I was mesmerized by the cells “blowing up” under the influence of alternating electric fields or Tumor Treating Fields. At that time, he was trying to enlist sites to participate in Novocure’s EF-11 phase III clinical trial comparing a device that emits these fields to chemotherapy for recurrent glioblastoma. The device was strange because it required shaving of the patient’s head and applying to the scalp four transducer arrays and each one had a set of nine ceramic disks. There were wires connecting the arrays to a box that generated the electric fields. At that time, The Matrix and its sequels were topping the box office and permeating popular culture. I was wondering whether or not this was the beginning of a brain-machine interface for the treatment of brain cancer. But in all seriousness, two killer questions came to my mind after seeing the video that led to our research team’s long-term commitment in this scientific exploration: (1) Did the alternating electric fi
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