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Anaphylaxis, isolated generalised erythema and lack of efficacy: 3 case reports In a case series, 3 patients (1 woman and 2 men) aged 26–64 years were described, who developed anaphylaxis or generalised erythema during treatment with amoxicillin/clavulanic acid or cefazolin. The woman additionally exhibited ineffectiveness of prednisolone therapy [times to reactions onsets and outcomes not stated; not all indications, dosages and routes stated]. Case 1: A 64-year-old woman presented with palm and sole pruritus, malaise, and dyspnoea at 30 minutes after taking amoxicillin/clavulanic acid 500mg/62.5mg for a dental infection. She presented to her dentist, where she received steroid therapy with prednisolone 80mg. The treatment was ineffective, and the reaction worsened (manifesting with vomiting, loss of consciousness and systolic pressure 60mm Hg). Epinephrine [adrenaline] was administered, and she was shifted to the emergency department. Her concomitant medications included infliximab and levothyroxine sodium [L-thyroxine]. Four weeks later, skin-test (ST) results to benzylpenicillin [penicillin G], amoxicillin/clavulanic acid and ampicillin were all negative on immediate reading. However, she mentioned that a late reaction at the previous ST had occurred. Intradermal tests (IDTs) were repeated and revealed again negative immediate reading. However, 4 and 6 hours later a dose-dependent wheal for IDTs to amoxicillin/clavulanic acid and ampicillin was noted, fading over the following days. She was considered allergic to amoxicillin/clavulanic acid and ampicillin. Case 2: A 26-year-old man was on norepinephrine [noradrenaline] for circulatory instability following a trauma. He received general anesthesia induction. Following achievement of circulatory stability, he presented to emergency orthopedic surgery (where propofol, sufentanyl, and paracetamol were administered). Two hours after surgery initiation and 30 minutes after the (presumably) second injection of IV amoxicillin/clavulanic acid 2g, he seemed to have received amoxicillin/clavulanic acid and concomitant gentamicin, while in the emergency unit. He experienced rapidly increasing circulatory instability, requiring increased doses of norepinephrine [noradrenalin], followed by epinephrine [adrenalin] syringe pump. Following cardio-circulatory recovery, he developed urticaria. ST results with benzylpenicillin, amoxicillin/clavulanic acid and ampicillin 6 weeks later were negative on immediate reading. However, when he reported a late reaction on the previous ST, that lasted for several days. IDTs were repeated, revealing negative immediate reading, yet wheal and flare were reported with benzylpenicillin, amoxicillin/clavulanic acid and ampicillin 24 hours later, lasting for several days with an accompanying lymphangitis on day 3. Further allergy workup returned negative. He was considered allergic to penicillins. Of note, he tolerated cefuroxime and ceftriaxone. Case 3: A 49-year-old man presented at 1-hour and 30 minutes following initiation of renal stent