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Anuric acute kidney injury: case report A 50-year-old man developed anuric acute kidney injury during treatment with amphotericin-b-liposomal for blastomycoses pneumonia. The man, who was diagnosed with blastomycoses pneumonia, started receiving amphotericin-b-liposomal [liposomal amphotericin B; route and dosage not stated]. Subsequently, he developed anuric acute kidney injury [duration of treatment to reaction onset not stated] and respiratory failure. The man required mechanical ventilation, veno-venous extracorporeal membrane oxygenation (VV ECMO) and continuous renal replacement therapy following hospitalisation. On day 4, the amphotericin-b-liposomal level was measured; however, there was an undetectable trough level based on high performance liquid chromatography assay. On the same day, there was a sharp rise in the transmembrane pressure gradient. Therefore, an ECMO circuit was replacement and consequently, a significant improvement was noted in transmembrane pressure gradient. Subsequently, his amphotericin-b-liposomal therapy was changed to amphotericin-B [amphotericin b deoxycholate]. He improved clinically after being switched to the deoxycholate formulation. Branick K, et al. Experience with liposomal amphotericin b in a patient with disseminated blastomycosis receiving extracorporeal membrane oxygenation and continuous renal replacement therapy. American Journal of Respiratory and Critical Care Medicine 199: (plus poster) abstr. A1747, No. 9, May 2019. Available from: URL: https:// 803446454 www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A1747 [abstract]

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Reactions 18 Jan 2020 No. 1787