Anterior segment optical coherence tomography features of pseudoepitheliomatous hyperplasia of the ocular surface: a stu
- PDF / 1,085,310 Bytes
- 7 Pages / 547.087 x 737.008 pts Page_size
- 29 Downloads / 197 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
ORIGINAL PAPER
Anterior segment optical coherence tomography features of pseudoepitheliomatous hyperplasia of the ocular surface: a study of 9 lesions Swathi Kaliki
. Arpita Maniar . Saumya Jakati . Dilip K. Mishra
Received: 19 June 2020 / Accepted: 16 August 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To describe anterior segment optical coherence tomography (AS-OCT) features of pseudoepitheliomatous hyperplasia (PEH) of the ocular surface. Methods This is a retrospective study of 9 lesions of 8 patients with histopathologically proven PEH Results Mean age at diagnosis of PEH was 31 years (median 31 years; range 12 to 62 years). The lesion was unilateral in 7 (88%) patients and bilateral in one (12%). Two patients (25%) had xeroderma pigmentosum, who also had a history of prior surgical intervention in the same eye for conjunctival tumor excision. Referral diagnosis was ocular surface squamous neoplasia (OSSN) in all cases. Ocular surface mass (n = 4, 44%) was the most common presenting complaint. The mean duration of symptoms was 18 months (median 3 months; range \ 1 to 84 months). All lesions were perilimbal, and the mean basal diameter of the tumor was 7 mm (median 6 mm; range 4 to 12 mm). Clinical diagnosis included OSSN (n = 5; 56%), PEH (n = 3; 33%), or leiomyosarcoma (n = 1; 11%). AS-OCT features included irregular hyperreflective epithelium, epithelial dipping, and S. Kaliki (&) A. Maniar Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad 500034, India e-mail: [email protected] S. Jakati D. K. Mishra Ophthalmic Pathology Services, L V Prasad Eye Institute, Hyderabad, India
subepithelial hyperreflective lesion with posterior shadowing in all cases. Histopathology confirmed the diagnosis of PEH in all cases. The underlying cause of PEH in these cases included vernal keratoconjunctivitis (n = 4; 44%), idiopathic severe blepharitis (n = 2; 22%), or prior surgical intervention (n = 2; 22%). No apparent cause could be determined in one eye (11%). Conclusion Ocular surface PEH is a close mimicker of OSSN. Careful history-taking, clinical examination, and characteristic AS-OCT features aid in accurate diagnosis. Keywords Eye Tumor Conjunctiva Ocular surface Pseudoepitheliomatous hyperplasia Ocular surface squamous neoplasia OSSN
Introduction Periocular pseudoepitheliomatous hyperplasia (PEH) is a benign condition of the eyelid, conjunctiva, or corneal epithelium occurring in response to an inciting pathology causing localized reactive inflammation. Conjunctival PEH usually presents as a limbal mass. Few reports in the literature have described the occurrence of conjunctival PEH in cases of vernal keratoconjunctivitis (VKC), postcultivated limbal epithelial transplantation (CLET), healed trachoma,
123
Int Ophthalmol
and granular cell tumor of the palpebral conjunctiva [1–6]. Clinically it mimics ocular surface squamous neoplasia (OSSN), often resulting in misdiagnosis. The diagnosis of PEH is
Data Loading...
