Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners
- PDF / 535,569 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 17 Downloads / 192 Views
Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners Tim J. Hartung 1 & Ida Rask Moustsen 2 & Signe Benzon Larsen 2,3 & Elisabeth A. Wreford Andersen 4 & Nis P. Suppli 5 & Christoffer Johansen 1,2,6 & Anne Tjønneland 7,8 & Anne S. Friberg 2,6 & Susanne K. Kjær 9,10 & Klaus Brasso 3 & Lars V. Kessing 11,12 & Anja Mehnert 1 & Susanne Oksbjerg Dalton 2 Received: 26 February 2020 / Accepted: 28 September 2020 # The Author(s) 2020
Abstract Purpose To estimate the risk of first-time antidepressant prescriptions as a proxy for depression or anxiety and associated risk factors in patients with prostate cancer and their female partners. Methods We followed all men (n = 25,126) and their female cohabiting partners (n = 8785) without a history of cancer or antidepressants from the Danish Diet, Cancer and Health cohort from 1997 to 2014 or 2010, respectively. We estimated the cumulative incidence of first-time antidepressant prescriptions in men with prostate cancer compared with cancer-free men and their respective female partners, using the Danish National Prescription Registry. Sociodemographic, lifestyle-related, and clinical risk factors were assessed using Cox regression models. Results A total of 1828 men were diagnosed with prostate cancer of whom 15% received antidepressants. The unadjusted hazard ratio of antidepressant prescription was 2.18 (95%CI, 1.92, 2.48) for men with prostate cancer and 1.27 (95%CI, 0.87, 1.85) for their partners, compared with cancer-free men and their partners, respectively. After adjusting for sociodemographic, lifestylerelated, and comorbidity factors, this risk was 2-fold to 4-fold increased among patients, but not significantly increased among partners. Significant risk factors among patients were curative and palliative treatment (vs. active surveillance and watchful waiting), nonlocalized disease, and short education. Conclusions Men with prostate cancer have a higher risk of receiving antidepressant medication than cancer-free men. Clinical characteristics can help clinicians in identifying patients at a high risk of depression or anxiety.
Previous presentation of the study Preliminary results of this study were presented at the European Cancer Rehabilitation and Survivorship Symposium in Copenhagen, Denmark, on September 11, 2018. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11764-020-00947-y) contains supplementary material, which is available to authorized users. * Tim J. Hartung [email protected] 1
Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Philipp-Rosenthal-Strasse 55, 04103 Leipzig, Germany
6
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
7
Danish Cancer Society Research Center, Copenhagen, Denmark
8
Department of Public Health, University of Copenhagen, Copenhagen, Denmark
2
Unit of Survivorship, The Danish Cancer Society Research Center, Copenhagen, Denmark
Data Loading...
